Hereditary susceptibility to endometrial cancer

Czech version

Authors: Michal Zikán; J. Sláma; I. Pinkavová; D. Fischerová; P. Freitag; D. Cibula
Authors‘ workplace: Onkogynekologické centrum, Gynekologicko-porodnická klinika 1. LF UK a VFN, Praha, přednosta prof. MUDr. A. Martan, DrSc.
Published in: Ceska Gynekol 2011; 76(3): 176-179

Overview

Objective:
To present up-to-date knowledge concerning field of hereditary susceptibility to endometrial cancer as a part of hereditary non-polyposis colorectal cancer (Lynch syndrome).

Subject:
Review.

Setting:
Oncogynecological Center, Department of Obstetrics and Gynecology, Charles University in Prague, First Faculty of Medicine and General Faculty Hospital, Prague.

Subject and method:
After having gone over the now-a-days literature and summarized our experience with management of high risk women of Lynch syndrome families we present up-to-date overview of this field problematics.

Conclusion:
Although endometrial cancer arising due to germ-line susceptibility account for a small part of these malignancies only, they represent disease with clearly defined and detectable serious risk factor. Management approach for these women is now defined and allows for early detection or lowering the risk. Educated gynecologist, as a field specialist, has good chance to identify women at risk and manage them in an appropriate way.

Key words:
hereditary non-polyposis colorectal cancer syndrom, mismatch repair system, Lynch syndrome, endometrial cancer.

Sources

1. Lalloo, F., ed. Risk assesement and management in cancer genetics. Oxford: Oxford University Press, 2005, 274 p.

2. Lu, KH., Broaddus, RR. Gynecologic Cancers in Lynch Syndrome/HNPCC. Fam Cancer, 2005, 4, 3, p. 249-254.

3. Lu, KH., Dinh, M., Kohlmann, W., et al. Gynecologic cancer as a “sentinel cancer” for women with hereditary nonpolyposis colorectal cancer syndrome. Obstet Gynecol, 2005, 105, 3, p. 569‑574.

4. Lynch, HT., de la Chapellem A. Genetic susceptibility to non-polyposis colorectal cancer. J Med Genet, 1999, 36, 11, p. 801-818.

5. Modugno, F. Ovarian cancer and high-risk women-implications for prevention, screening, and early detection. Gynecol Oncol, 2003, 91, 1, p. 15-31.

6. Umar, A., Boland, CR., Terdiman, JP., et al. Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst, 2004, 96, 4, p. 261-268.

7. Vasen, HF., Watson, P., Mecklin, JP., Lynch, HT. New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC. Gastroenterology, 1999, 116, 6, p. 1453-1456.

8. Zikan, M., Foretova, L., Cibula, D., et al. [Hereditary ovarian cancer]. Čes Gynek, 2006, 71, 3, p. 246-251.

9. Zikan, M., Jancarkova, N., Pohlreich, P., et al. [Hereditary predisposition for the development of breast and ovarian carcinoma]. Čas lek Čes, 2004, 143, 1, p. 26-30.