Luteal support in the IVF/ET programme

Czech version

Authors: Ľ. Michnová ¹; T. Rumpíková ²; J. Dostál ¹
Authors‘ workplace: Porodnicko-gynekologická klinika, FN a LF UP Olomouc, přednosta doc. MUDr. R. Pilka, Ph. D. ¹; Klinika reprodukční medicíny a gynekologie Zlín, vedoucí lékař prof. MUDr. L. Pilka, DrSc. ²
Published in: Ceska Gynekol 2011; 76(2): 104-107

Overview

Objective:
The objective of this article is to review the recent information about luteal support in the IVF/ET programme.

Design:
Review article.

Conclusions:
The luteal phase support is a necessary part of treatment in stimulated cycles for IVF/ET.

Key words:
luteal phase support, IVF/ET.

Sources

1. Anthony, FW., Smith, EM., Gadd, SC., et al. Placental protein 14 secretion during in vitro fertilization cycles with and without human chorionic gonadotropin for luteal support. Fertil Steril, 1993, 59, 1, p. 187-191.

2. Araujo, E. Jr., Bernardini, L., Frederick, JL., et al. Prospective randomized comparison of human chorionic gonadotropin versus intramuscular progesterone for luteal-phase support in assisted reproduction. J Assist Reprod Genet, 1994, 11, 2, p. 74‑78.

3. Beckers, NG., Laven, JS., Eijkemans, MJ., Fauser, BC. Follicular and luteal phase characteristics following early cessation of gonadotrophin-releasing hormone agonist during ovarian stimulation for in-vitro fertilization. Hum Reprod, 2000, 15, 1, p. 43-49.

4. Beckers, NG., Macklon, NS., Eijkemans, MJ., et al. Nonsupplemented luteal phase characteristics after the administration of recombinant human chorionic gonadotropin, recombinant luteinizing hormone, or gonadotropin-releasing hormone (GnRH) agonist to induce final oocyte maturation in in vitro fertilization patients after ovarian stimulation with recombinant follicle-stimulating hormone and GnRH antagonist cotreatment. J Clin Endocrinol Metab, 2003, 88, 9, p. 4186-4192.

5. Beckers, NG., Platteau, P., Eijkemans, MJ., et al. The early luteal phase administration of estrogen and progesterone does not induce premature luteolysis in normo-ovulatory women. Eur J Endocrinol, 2006, 155, 2, p. 355-363.

6. Bouckaert, Y., Robert, F., Englert, Y., et al. Acute eosinophilic pneumonia associated with intramuscular administration of progesterone as luteal phase support after IVF: case report. Hum Reprod, 2004, 19, 8, p. 1806-1810.

7. Bourgain, C., Devroey, P., Van Waesberghe, L., et al. Effects of natural progesterone on the morphology of the endometrium in patients with primary ovarian failure. Hum Reprod, 1990, 5, 5, p. 537-543.

8. Cicinelli, E., de Ziegler, D., Bulletti, C., et al. Direct transport of progesterone from vagina to uterus. Obstet Gynecol, 2000, 95, 3, p. 403-406.

9. Csapo, AI., Pulkkinen, MO., Ruttner, B., et al. The significance of the human corpus luteum in pregnancy maintenance. I. Preliminary studies. Am J Obstet Gynecol, 1972, 112, 8, p. 1061-1067.

10. Csapo, AI., Pulkkinen, MO., Wiest, WG. Effects of luteectomy and progesterone replacement therapy in early pregnant patients. Am J Obstet Gynecol, 1973, 115, 6, p. 759-765.

11. de Ziegler, D., Seidler, L., Schärer, E., et al. Non-oral administration of progesterone: experiences and possibilities of the transvaginal route. Praxis, 1995, 84, 5, p.127-133.

12. Devoto, L., Vega, M., Kohen, P., et al. Endocrine and paracrine-autocrine regulation of the human corpus luteum during the mid-luteal phase. J Reprod Fertil, 2000, suppl., 55, p. 13-20.

13. Edwards, RG. An introduction to Bourn Hall: the biomedical backround of the Bourn Hall Clinic. In Brinsden, P. (ed.) Textbook of in vitro fertilization and assisted reproduction. 3rd ed. London: Informa Healthcare, 2007, p. 1-7.

14. Edwards, RG., Steptoe, PC., Purdy, JM. Establishing full-term human pregnancies using cleaving embryos grown in vitro. Br J Obstet Gynaecol, 1980, 87, 9, p. 737-756.

15. Farhi, J., Weissman, A., Steinfeld, Z., et al. Estradiol supplementation during the luteal phase may improve the pregnancy rate in patients undergoing in vitro fertilization-embryo transfer cycles. Fertil Steril, 2000, 73, 4, p. 761-766.

16. Fatemi, HM., Popovic-Todorovic, B., Papanikolaou, E., et al. An update of luteal phase support in stimulated IVF cycles. Hum Reprod Update, 2007, 13, 6, p. 581-590.

17. Fauser, BC., Devroey, P. Reproductive biology and IVF: ovarian stimulation and luteal phase consequences. Trends Endocrinol Metab, 2003, 14, 5, 236-242.

18. Ghosh, D., Stewart, DR., Nayak, NR., et al. Serum concentrations of oestradiol-17beta, progesterone, relaxin and chorionic gonadotrophin during blastocyst implantation in natural pregnancy cycle and in embryo transfer cycle in the rhesus monkey. Hum Reprod, 1997, 12, 5, p. 914-920.

19. Harper, MJ. The implantation window. Baillieres Clin Obstet Gynaecol, 1992, 6, 2, p. 351-371.

20. Hild-Petito, S., Fazleabas, AT. Expression of steroid receptors and steroidogenic enzymes in the baboon (Papio anubis) corpus luteum during the menstrual cycle and early pregnancy. J Clin Endocrinol Metab, 1997, 82, 3, p. 955-962.

21. Hohmann, FP., Laven, JS., de Jong, FH., et al. Low-dose exogenous FSH initiated during the early, mid or late follicular phase can induce multiple dominant follicle development. Hum Reprod, 2001, 16, 5, p. 846-854.

22. Honda, T., Fujiwara, H., Yamada, S., et al. Integrin alpha5 is expressed on human luteinizing granulosa cells during corpus luteum formation, and its expression is enhanced by human chorionic gonadotrophin in vitro. Mol Hum Reprod, 1997, 3, 11, p. 979-984.

23. Chakravarty, BN., Shirazee, HH., Dam, P., et al. Oral dydrogesterone versus intravaginal micronised progesterone as luteal phase support in assisted reproductive technology (ART) cycles: results of a randomised study. J Steroid Biochem Mol Biol, 2005, 97, 5, p. 416-420.

24. Jones, HW. Jr., Jones, GS., Hodgen GD., Rosenwaks, Z. (eds.) IVF-Norfolk. 1st ed. Baltimore: Williams & Wilkins, 1986, 232 p.

25. Kolibianakis, EM., Venetis, CA., Papanikolaou, EG., et al. Estrogen addition to progesterone for luteal phase support in cycles stimulated with GnRH analogues and gonadotrophins for IVF: a systematic review and meta-analysis. Hum Reprod, 2008, 23, 6, p. 1346-1354.

26. Lejeune, B., Camus, M., Deschacht, J., Leroy, F. Differences in the luteal phases after failed or successful in vitro fertilization and embryo replacement. J In Vitro Fert Embryo Transf, 1986, 3, 6, p. 358-365.

27. Levine, H. Luteal support in IVF using the novel vaginal progesterone gel Crinone 8%: results of an open-label trial in 1184 women from 16 US centers. Fertil Steril, 2000, 74, 4, 836-837.

28. Ludwig, M., Schwartz, P., Babahan, B., et al. Luteal phase support using either Crinone 8% or Utrogest: results of a prospective, randomized study. Eur J Obstet Gynecol Reprod Biol, 2002, 103, 1, p. 48-52.

29. Minas, V., Loutradis, D., Makrigiannakis, A. Factors controlling blastocyst implantation. Reprod Biomed Online, 2005, 10, 2, p. 205-216.

30. Nosarka, S., Kruger, T., Siebert, I., Grové, D. Luteal phase support in in vitro fertilization: meta-analysis of randomized trials. Gynecol Obstet Invest, 2005, 60, 2, p. 67-74.

31. Nyboe Andersen, A., Popovic-Todorovic, B., Schmidt, KT., et al. Progesterone supplementation during early gestations after IVF or ICSI has no effect on the delivery rates: a randomized controlled trial. Hum Reprod, 2002, 17, 2, p. 357-361.

32. Penzias, AS. Luteal phase support. Fertil Steril. 2002, 77, 2, p. 318-323.

33. Pritts, EA., Atwood, AK. Luteal phase support in infertility treatment: a meta-analysis of the randomized trials. Hum Reprod, 2002, 17, 9, p. 2287-2299.

34. Proctor, A., Hurst, BS., Marshburn, PB., et al. Effect of progesterone supplementation in early pregnancy on the pregnancy outcome after in vitro fertilization. Fertil Steril, 2006, 85, 5, p. 1550-1552.

35. Propst, AM., Hill, JA., Ginsburg, ES., et al. A randomized study comparing Crinone 8% and intramuscular progesterone supplementation in in vitro fertilization-embryo transfer cycles. Fertil Steril, 2001, 76, 6, p. 1144-1149.

36. Scott, R., Navot, D., Liu, HC., Rosenwaks, Z. A human in vivo model for the luteoplacental shift. Fertil Steril, 1991, 56, 3, p. 481-484.

37. Simunic, V., Tomic, V., Tomic, J., Nizic D. Comparative study of the efficacy and tolerability of two vaginal progesterone formulations, Crinone 8% gel and Utrogestan capsules, used for luteal support. Fertil Steril, 2007, 87, 1, p. 83-87.

38. Smitz, J., Devroey, P., Camus, M., et al. The luteal phase and early pregnancy after combined GnRH-agonist/HMG treatment for superovulation in IVF or GIFT. Hum Reprod, 1988, 3, 5, p. 585-590.

39. Toner, JP. The luteal phase: luteal support protocols. In Gardner, DK., Weissman, A., Howles, CM., et al. (eds.) Textbook of assisted reproductive techniques. 2nd ed. London: Tailor & Francis, 2004, p. 639-650.

40. Vande Wiele, RL., Bogumil, J., Dyrenfurth, I., et al. Mechanisms regulating the menstrual cycle in women. Recent Prog Horm Res, 1970, 26, p. 63-103.

41. Whelan, JG. 3rd, Vlahos, NF. The ovarian hyperstimulation syndrome. Fertil Steril, 2000, 73, 5, p. 883-896.