Proteomics and biomarkers for detection of preterm labor: a systematic review

Czech version

Authors: I. Musilová; M. Kacerovský; V. Tambor; J. Tošner
Authors‘ workplace: Porodnická a gynekologická klinika FN Hradec Králové a Lékařské fakulty Hradec Králové, UK Praha, přednosta doc. MUDr. J. Tošner, CSc.
Published in: Ceska Gynekol 2011; 76(1): 37-45

Overview

Objective:
To review the published articles about identification of biomarkers of spontaneous preterm birth using a proteomic approach and to create a list of potential biomarkers.

Design:
Systematic review of literature.

Setting:
Department of Obstetrics and Gynecology, Medical Faculty Charles University Hradec Kralove.

Methods:
The following databases were accessed in search of relevant citation: MEDLINE, SCOPUS and PubMed. Totally 101 references were identified and relevant 37 abstracts were screened. As appropriated were pointed 16 studies. Finally, the data were extracted from five articles.

Conclusion:
The implementation of high-throughput technologies is necessary in the field of spontaneous preterm birth research. A compelling option is the use of proteomics in the area spontaneous preterm birth biomarkers identification in amniotic fluid, maternal serum/plasma, cervical-vaginal fluid and placental tissue. The data was extracted from published articles and a list of 72 proteins was created.

Key words:
spontaneous preterm birth, proteomics, biomarker.

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