Pregnant women alloimmunisation of non-RhD erythrocyte antigens: review article

Czech version

Authors: M. Pětroš ¹; M. Lubušký ^2,3; O. Šimetka ¹; M. Procházka ^2,3
Authors‘ workplace: Porodnicko-gynekologická klinika, Fakultní nemocnice Ostrava, přednosta MUDr. O. Šimetka ¹; Porodnicko-gynekologická klinika, Fakultní nemocnice Olomouc, přednosta doc. MUDr. R. Pilka, Ph. D. ²; Ústav lékařské genetiky a fetální medicíny, Fakultní nemocnice Olomouc, přednosta prof. MUDr. J. Šantavý, CSc. ³
Published in: Ceska Gynekol 2010; 75(4): 325-333

Overview

Cíl studie:
Cílem tohoto přehledu je dát ucelený pohled na aloimunizaci non-RhD erytrocytárními antigeny.

Typ studie:
Přehledová práce.

Název a sídlo pracoviště:
Porodnicko-gynekologická klinika, Fakultní nemocnice Ostrava. Porodnicko-gynekologická klinika, Fakultní nemocnice Olomouc, Ústav lékařské genetiky a fetální medicíny, Fakultní nemocnice Olomouc.

Předmět a metodika studie:
Na základě analýzy publikací vyhledaných v databázích PubMed, Google Scholar, Ovid a Proquest zaměřeného na jednotlivé non–RhD aloprotilátky byl sestaven současný přehled znalostí.

Závěr:
Aloimunizace těhotných žen non-RhD erytrocytárními antigeny nabývá na důležitosti v souvislosti s relativním vzestupem jejich výskytu. Profylaxe zde není možná. Nicméně i tyto erytrocytární antigeny mohou vyvolat u matky protilátkovou odpověď, která může vést k rozvoji hemolytické nemoci plodu i novorozence. V článku jsou diskutovány nejčastější typy non-RhD aloprotilátek.

Klíčová slova:
aloimunizace, non-RhD protilátky, prenatální diagnostika.

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