Authors: N. Jančárková 1; M. Krkavcová 2; M. Janashia 2; Freitag. P. 1 Authors‘ workplace: Gynekologicko-porodnická klinika 1. LF UK a VFN, Praha, přednosta prof. MUDr. A. Martan, DrSc. 1; Ústav biologie a lékařské genetiky 1. LF UK a VFN, Praha, přednostka doc. MUDr. M. Kohoutová, CSc. 2 Published in: Ceska Gynekol 2005; 70(4): 299-306 Category: Original Article
Objective: To sum up the knowledge about genetic aspects of ovarian cancer.
Type of study: Review article.
Setting: Department of Gynecology and Obstetrics, First Faculty of Medicine, Charles University Prague and General Teaching Hospital Prague, Prague.
Methods: Compilation of data from scientific literature.
Conclusions: Ovarian cancer represents the most lethal malignancy among gynecological tumours. Etiology is still largely unknown. Multistep process, with accumulation of genetic alterations concerning factors with key role in cell regulation – oncogenes, tumor-supressor genes and mismatch-repair genes is supposed. Cytogenetic and molecular-genetic characteristics, in correlation with other molecular-biological parameters extend information of carcinogenesis. The final aim is to create a predictive model for clinical use.
Key words: ovarian cancer, oncogenes, tumor-supressor genes, mismatch-repair genes, genetic alteration
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