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Borderline Ovarian Tumors – 10-year Clinical Series andLiterature Review


Authors: P. Freitag;  N. Jančárková;  D. Fischerová;  D. Cibula;  J. Živný
Authors‘ workplace: Gynekologicko-porodnická klinika 1. LF UK a VFN, Praha, přednosta prof. MUDr. J. Živný, DrSc.
Published in: Ceska Gynekol 2004; (4): 278-282
Category:

Overview

Objective:
Analysis of 10-year clinical series of borderline ovarian tumors (BLT) and literaturereview.Design: Retrospective clinical study.Setting: Department of Obstetrics and Gynaecology, 1st Medical Faculty, Charles University andGeneral Faculty Hospital, Prague.Methods: Analysis of 38 patients from years 1994-2003 regarding age, histological types, tumorduplicities, role of frozen section, Ca125 levels, operation methods, adjuvant treatment, relapsoccurrence, follow-up and survival.Results: Median follow-up was 18.5 months (3-122), median age 51 (16-78). Histology: 23 serous,12 mucinous (1 microinvasion), 2 cystadenofi bromas and 1 endosalpingiosis. 26 patients ofstage IA, 3 of IB, 6 of IC, 1 of IIA, 1 of IIC and 1 IIIB. 3 cases were underestimated by frozen section.6 tumor duplicities were revealed. Ca 125 marker was elevated in 10/23 (43.5%) cases. 12patients underwent conservative surgery, 3 of them with complete staging including lymphadenectomy.26 patients had radical operation, 9 of them with full staging. No one lymphonodewas positive. 7 patients had primary laparoscopic approach, 6 had more than one operation.Adjuvant chemotherapy was indicated in 3 cases: PTX-CBDCA (IC and IIC) and CBDCA-CFA(IC). 4 patients were lost of evidence. 2/34 evaluated patients (5.9%) had a frank carcinomarecurrence after 3 and 7 years. Both relapsed patients and all 34 evaluable patients live withoutevidence of disease at present. Our results as well as literature date generate some controversies.Do we need staging lymphadenectomy in all cases (inclusive T1a)? Which parametersidentify high-risk group and which patients will benefi t from adjuvant (and which one) therapy?Are there not recurrencies of BLT rather second primary malignancies?Conclusion: In spite of 2 recurrences in a group of 34 evaluated cases all patients live withoutevidence of disease at present. Some management questions are therefore raised.

Key words:
borderline ovarian tumor

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Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine

Article was published in

Czech Gynaecology


2004 Issue 4

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