Antizonal Antibodies in Ovulatory Cervical Mucus andin Serum of Patients with Fertility Disorders

Czech version

Authors: Z. Ulčová-Gallová; K. Babčová; P. Nováková; Z. Mičanová; Z. Rokyta
Authors‘ workplace: Gynekologicko-porodnická klinika LF UK a FN, Plzeň, přednosta doc. MUDr. Z. Rokyta, CSc.
Published in: Ceska Gynekol 2004; (3): 215-218
Category:

Overview

Objective:
Detection of antizonal antibodies (aZPs) in cervical ovulatory mucus and in serum inpatients with fertility failure.Design: Retrospective study.Setting: Department of Gynaecology and Obstetrics, Medical Faculty of Charles University, andFaculty Hospital, Plzeň.Methods: Detection of aZPs (passive haemagglutation test) in cervical ovulatory mucus (OM) andin serum from 105 patients with reproductive failure and in 25 fertile healthy women (controlgroup).Results: Positive levels of aZP in OM were found in 79 (75.2%) patients, in 56 of them aZP wereobserved in OM and in serum together, only ovulatory aZPs in 23 (21.9%), and only serum aZPs in18 (17.1%) were found. aZPs predominate in 47 patients (of 48 women) with more than two in vitrofertilization processes, in thirty of them aZPs in serum and in OM together were observed. On theonother hand, repeated spontaneous miscarriage and obesity have no connection with detectionof aZPs in our patients.Conclusion: The increased levels of serum and OM aZPs are very often seen in patients after repeatedusuccessful IVF. This very important result in reproductive imunology means to go on the micromanipulationtechnics combined with immunossuppression in the next planned IVF procedure.

Key words:
antizonal antibodies, fertility disorders

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