Arrest of Lactation after Abortion during the SecondTrimester of Pregnancy by Administration of a SingleDose of Cabergoline as Compared with Ten-dayTerguride Administration

Overview

Objective:
The objective of the work was to compare the effectiveness and tolerance of a singleadministration of 1 mg cabergoline and 10-day administration of 1.5 mg terguride divided intothree doses after 8-hour intervals, in the indication of arrest of lactation after an abortion duringthe second trimester.Type of study: Prospective clinical study.Name and place of department: Gynaecological and Obstetric Clinic. First Medical Faculty CharlesUniversity and General Faculty Hospital Prague, Apolinářská 18, Prague 2. Method: During the period between January and October 2000 to 41 patients after abortioninduced during the 2nd trimester terguride, 0.5 mg after 8-hour intervals, was administered fora 10-day period. During the subsequent period from November 2000 to September 2001 to 43patients cabergoline was administered in a single dose within 12 hours after the abortion. Duringhospitalization the patients were asked daily for their subjective evaluation of the effect of treatment(vertigo, palpitations, headache, nausea, vomiting, abdominal pain, sleepiness, secretionfrom the breast, tension in the breasts) and the doctor evaluated the success of treatment objectively.Within 21 days after the abortion the patients were addressed over the phone on subjectiveand objective effects of treatment. For statistical evaluation Fisher’s exact bilateral test was used.Results: The „cabergoline” group displayed, as compared with the „terguride” group, significantlyfewer undesirable effects (p

Key words:
arrest of lactation, abortion, second trimester