Prediction of Prematurity: Multi-dimensional Analysisof a Prospective Clinical Study

Overview

Objective:
To evaluate, which of selected anamnestic, laboratory and ultrasonographic (USG)parameters could contribute to the prediction of prematurity.Design: Prospective, observational, clinical study.Setting: Department of Obstetrics and Gynecology, 1stFaculty of Medicine and the General Facul-ty Hospital, Charles University, Prague. Methods: 349 women with the singleton pregnancy were followed from the half of the 2ndtrimes-ter untill the end of gestation. At each woman the anamnestic (age, parity, pregravid BMI, weightgain untill 20thweek, significant risk from patient’s history, cigarette smoking, risk pregnancysymptoms untill 20thweek), laboratory (maternal serum concentration of AFP, hCG, and uE3/triple test/ at 16thweek, the blood count and ferritin concentration at 18th–20thweek, bacteriolo-gical cultivation of the smear from the cervix at 34th–36thweek), and USG (transvaginal cervico-metry and doppler flowmetry of the uterine arteries at 18th–20thweek) data were established.With the aid of one-dimensional and multi-dimensional analysis the dependence of completedgestational age and preterm delivery (before completed 37thweek) on above mentioned parame-ters was tested.Results: 314 women completed the study. We proved a significant dependence of prematurity onthe following markers: risk pregnancy symptoms until 20thweek (RR 2.94), abnormal triple test(RR 4.63), cultivation of pathogens from the cervix (RR 5.49), USG established cervical length(P

Key words:
cervicometry, multi-dimensional analysis, prediction, prematurity, screening