#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

The Roleof Antisperm Autoantibodies and Cell-mediated Autoimmunity inthe Pathogenesis of Male Infertility


Authors: J. Madar;  V. Urbánek;  A. Chaloupková;  K. Nouza;  R. Kinský
Authors‘ workplace: Ústav pro péči o matku a dítě, Praha, ředitel doc. MUDr. J. Feyereisl, CSc. Sexuologický ústav 1. LF UK a VFN, Praha, ředitel doc. MUDr. J. Zvěřina, CSc. Ústav molekulární genetiky AV ČR, Praha, ředitel prof. RNDr. V. Pačes, DrSc.
Published in: Ceska Gynekol 2002; (1): 3-7
Category:

Overview

Objective:
To test the hypothesis of relationship between sperm pathology and elevated humoraland/or cell-mediated antisperm autoimmunity in male partners from infertile couples.Design: Analytic study.Setting: Department of Immunobiology, Institute for the Care of Mother and Child, Prague.Methods: Sperm samples were evaluated according to WHO rules. Sperm-bound antisperm autoantibodies (ASA) were determined by SpermMar Test (FertiPro N. V., Sint-Martens-Latem, Belgium). For evaluation of cell-mediated antisperm autoimmunity (CMAA) the authors used their ownmodification of migration-inhibition test (Dimitrov et al., J. Immunol. Methods 154: 147, 1992).Results: The pool of men was divided into groups according to the result of sperm examination:normozoospermia (740 men), asthenozoospermia (244), teratozoospermia (191), oligoasthenozoospermia levis (61), oligoasthenozoospermia gravis (29), oligoteratozoospermia (82), and azoospermia (54). Subgroup of fertile men (32) consisted of normozoospermic men – fathers of childyounger than 3 years. Percentage of sperm-bound ASA-positive samples was significantly higherin asthenozoospermia in comparison with normozoospermia in both IgA (20.8% versus 10.6%) andIgG classes (13.8% vs 6.8%). Positivity of CMAA was significantly more frequent in group ofasthenozoospermic (52%) than in normozoospermic (28.5%) and fertile (12.5%) men.Conclusion: Antisperm autoimunity, namely its cellediated form, appears to play a significantrole in impairment of spermiogenesis. Sperm-bound autoantibodies were found more frequentlyin asthenozoospermia, but also in some men with normozoospermia they may impair fertility.

Key words:
sperm pathology, antisperm autoantibodies, antisperm cell-mediated autoimmunity,male fertility

Full text is not available online.
If interested in a scan of this journal, contact NTO ČLS JEP.

Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#