HormonalSubstitution Treatment in Women Operated on Account of Endometriosisand Adenomyosis: Prospective Follow-up Study (Part II)

Czech version

Authors: Z. Holub; Z. Holub; H. Brožková; M. Kučera; J. Kračková; M. Martinovský; M. Müller; M. Poustková; A. Vančurová; J. Voráček; M. Wágnerová
Authors‘ workplace: Gynekologicko-porodnické oddělení, Nemocnice Kladno, primář doc. MUDr. Z. Holub, CSc. Gynekologické ambulance kladenského regionu
Published in: Ceska Gynekol 2001; (6): 405-408
Category:

Overview

Objective:
To determine whether the initiation of estrogen replacement therapy (ERT) in thepostoperative period increase the incidence of reoperative rate and symptomatic pelvic painfollowing laparoscopic hysterectomy (LH) and/without bilateral salpingo oophorectomy (BSO) forthe treatment of endometriosis and adenomyosis.Design: Prospective partially randomized patient preference follow-up trial (PRPPT).Setting: Department of Gynaecology, Endoscopic Training Centra, Kladno Hospital, Czech Republic.Methods: Chart review of 286 consecutive patients who underwent LH and/or without BSO forendometriosis or adenomyosis between April 1994 and June 1999 and whom subsequently wereproposed ERT 124 women with complete records were enrolled in the study and were randomizedto ERT group and control group. Statistical analysis was performed using t-test when appropria-te, with a level of significance P = 0.05.Results: The women were followed for 24-87 month. Five (6.7%) patients of the ERT group experi-enced recurrent endometriosis after previous surgery compared five (10.3%) patients in the con-trol group. This difference in reoperation rate was statistical insignificant. Seven (9.7%) patientsin the HRT group reported symptomatic pelvic pain compared with only one (2.04%) patient inthe control group (P

Key words:
endometriosis, hormonal replacement therapy, laparoscopic hysterectomy

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