Review Dental Treatment of Patients with Congenital Bleeding Disorders

Czech version

Authors: J. Papež; K. Chleborád; T. Dostálová
Authors‘ workplace: Stomatologická klinika dětí a dospělých 2. LF UK a FNM, Praha
Published in: Česká stomatologie / Praktické zubní lékařství, ročník 114, 2014, 6, s. 109-115
Category: Review Article

Overview

Objectives:
The commonest congenital bleeding disorders in childhood are hemophilia, von Willebrand disease and deficiency of factor XI. Disease is characterized by a deficient of coagulability. It is a gonosomal recessive condition. There are two main types of hemophilia: Hemophilia A is characterized by a deficiency of factor VIII (FVIII) and hemophilia B is characterized by a deficiency of factor IX (FIX). Hemophilia is an X-linked hereditary disorder and affects predominantly males because of their hemizygous (karyotyp 46, XY). Females – heterozygot (karyotyp 46, XX) are transmitter of gene for hemophilia and they are rarely affected unless there is an unequal lyonisation of the X – chromosome. There are two other common diseases which are needed to mention: von Willebrand disease and factor XI deficiency. Von Willebrand disease is the commonest congenital bleeding disorder on the other hand deficiency of factor XI is not so common. Both of them have similar clinical manifestation a treatment such as hemophilia. The provision of dental treatment in patients with congenital bleeding disorders has often been neglected. In past most treatments were carried out under general anesthesia and usually the only one treatment plan was extraction followed by provision of dentures. Since the introduction of coagulation factor, use new local hemostatic agents, improvement of operative methods, minimal invasive therapy and an increasing interest in the preventive of dental problems started new era in dental care for patients with congenital bleeding disorders. Nowadays use doctor during the intervention, replacement therapy to increase level of FVIII, FIX, von Willebrand factor and factor XI prophylactic factor with combination fibrin glue, antifibrinolytic agents and other agents which make treatment faster, safe and more comfortable. Point of this article is to provide other dentists general informatics about healing patients with congenital bleeding disorders.

Keywords:
hemophilia A – hemophilia B – von Willebrand disease – factor XI deficiency – orthodontic treatment – anesthesia – periodontal disease – oral surgical procedures – dental extraction – fibrin glue

Sources

1. Anderson, J. A. M., Brewer, A., Creagh, D., Hook, S., Mainwaring, J., McKernan, A., Yee T. T., Yeung C. A.: Guidance on the dental management of patients with haemophilia and congenital bleeding disorders. Brit. Dent. J., roč. 215, 2013, č. 10, s. 497–504.

2. Belozerskaya, G. G., Makarov, V. A., Zhidkov, E. A., Malykhina, L. S.: Local hemostatics (a review). Pharmaceutical Chem. J., roč. 40, 2006, č. 40, s. 353–359.

4. Bolton-Maggs, P. H. B.: Factor XI deficiency and its management, World Federation of Hemophilia, Treatment of Hemophilia, č. 16, 2008, s. 1–18.

5. Brewer, A. K., Correa, M. E.: Guidelines for dental treatment of patients with inherited bleeding disorders, World Federation of Hemophilia Treatment of Hemophilia, č. 40, 2006.

6. Brewer, A. K., Roebuck, E. M., Donachie, M., Hazard, A., Gordon, K., Fung, D., Clarkson, J.: The dental management of adult patients with haemophilia and other congenital bleeding disorders. Haemophilia, roč. 9, 2003, č. 6, s. 673–677.

7. Colvin, B. T., Astermark, J., Fischer, K., Gringeri, A., Lassila, R., Schramm, W., Thomas, A., Ingerslev, J.: European principles of haemophilia care. Haemophilia., roč. 14, 2008, č. 2, s. 361–374.

8. Dougall, A., Fiske, J.: Acces to special care dentistry. Brit. Dent. J., roč. 205, 2008, č. 5, s. 177–190.

9. Freedman, M., Dougall, A., White, B.: An audit of a protocol for the management of patients with hereditary bleeding disorders undergoing dental treatment. J. Disabil. Oral. Health, roč. 10, 2009, č. 4, s. 151–155.

10. Gibble, J. W., Ness, P. M.: Fibrin Glue: the perfect operative sealant. Transfusion, roč. 30, 1990, č. 8, s. 741–747.

11. Ginzelová, K., Hechtová, D.: Laryngeální maska v dětské stomatologii. Quintessenz., roč. 16, 2007, č. 5, s. 77–81.

12. Grossman, R. C.: Orthodontics and dentistry for the hemophilic patient. Am. J. Orthod., roč. 68, 1975, č. 4, s. 391–403.

13. Gupta, A., Epstein, J. B., Cabay, R. J.: Bleeding disorders of importace in dental care and related patient management. J. Can. Dent. Assoc., roč. 73, 2007, s. 77–83.

14. Heiland, M., Weber, M., Schmelzle, R.: Life – threatening bleeding after dental extraction in a haemophilia. A patient with inhibitors to factor VIII: a case report. J. Oral Maxillofac. Surg., roč. 61, 2003, č. 11, s. 1350–1353.

15. Chabbat, J., Tellier, M., Porte, P., et al.: Properties of a new fibrin glue stable in liquid state. Thrombosis Res., roč. 76, 1994, č. 6, s. 525–533.

16. Chleborád, K., Ginzelová, K., Dostálová, T.: Stomatologické ošetření dětského pacienta se středně těžkou formou hemofilie z ortodontických důvodů. LKS., roč. 20, 2010, č. 6, s. 134–137.

17. Chleborád, K., Ginzelová, K., Dostálová, T.: Stomatologické ošetření dětského pacienta s těžkou hemofilií. LKS., roč. 19, 2009, č. 3, s. 85–87.

18. Katz, J. O., Terezhalmy, G. T.: Dental management of the patient with haemophilia. Oral Surg. Oral Med. Oral Pathol., roč. 66, 1988, č. 1, s. 139–144.

19. Lee, A., Boyle, C. A., Savidge, G. F., Fiske, J.: Effectiveness in controlling haemorrhage after dental scaling in people with haemophilia by using tranexamic acid mouthwash. Brit. Dent. J., roč. 198, 2005, č. 1, s. 33–38.

20. Mannucci, P. M., Tuddenham, E. G.: The haemophilias – from royal genes to gene therapy. N. Engl. J. Med., roč. 345, 2001, č. 5, s. 1773–1779.

21. Mannucci, P. M.: Desmopressin (DDAVP) in the treatment of bleeding disorders: the first 20 years. Blood, roč. 90, 1997, č. 7, s. 2515–2521.

22. Scottish Dental Clinical Effectiveness Programme. Oral health assessment and review: guidance in brief. Dundee: Scottish Dental Clinical Effectiveness Programme, 2011.

23. Vinckier, F., Vermylen, J.: Dental extractions in hemophilia: reflections on 10 years´experience. Oral Surg. Oral Med. Oral Pathol., roč. 59, 1985, č. 1, s. 6–9.

24. Wilde, J. T., Cook, R. J.: von Willebrand disease and its management in oral and maxillofacial surgery. Brit. J. Oral Maxillofac. Surg., roč. 36, 1998, č. 2, s. 112–118.

Labels

Gynaecology and obstetrics Maxillofacial surgery Orthodontics Dental medicine

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Article was published in

Czech Dental Journal

2014 Issue 6