Diabetes Mellitus and Oral Health

Czech version

Authors: H. Poskerová ¹; P. Bořilová Linhartová ²; J. Vokurka ¹; A. Fassmann ¹; L. Izakovičová Hollá ^1,2
Authors‘ workplace: Stomatologická klinika LF MU a FN u sv. Anny, Brno ¹; Ústav patologické fyziologie LF MU a FN, Brno ²
Published in: Česká stomatologie / Praktické zubní lékařství, ročník 114, 2014, 5, s. 75-86
Category: Review Article

Práce je věnována prof. MUDr. Janu Kilianovi, DrSc., k jeho významnému životnímu jubileu

Overview

Background:
This review summarizes the current state of knowledge about the relationship between diabetes mellitus (DM) and diseases of the oral cavity tissues. In the introduction, the authors define diabetes including its classification, describe causes of DM origin as well as complications accompanying this disease. Further, the actual epidemiological data related to the diabetes occurrence in the Czech Republic and in the world are given. The authors summarize manifestation of DM in the oral cavity and its impact on the periodontal tissues (gingivitis and periodontitis), caries rate, state of the oral mucosa (oral candidiasis, oral lichen planus, atrophic glossitis, stomatodynia, glossodynia), state of the salivary glands (diabetic sialoadenosis), saliva formation, perception of taste stimuli and healing wounds in the oral cavity (extraction and other surgical treatments). The authors also explain in what manner and by which mechanisms the oral cavity tissues in DM patients are affected. The long-term increased blood glucose level leading to the origin of advanced glycation end products (AGEs) is considered as the main etiologic factor. These products together with other pathogenetic mechanisms (e.g. oxidative stress, polyol accumulation) lead to structural and functional alterations of capillaries, changes in collagen metabolism, functional changes of the immune cells, and bone metabolism. Study also shows a mutual relationship between DM and periodontitis and the effect of the periodontal treatment on this metabolic disease. The authors also consider effective prevention and insufficient motivation of diabetic patients for oral health care. In conclusion, results of the 9th European Workshop in Periodontology, which was held in Spain in autumn 2012 and focused on the relationship between periodontitis and systemic diseases, are mentioned together with the reference to the online proceedings of this conference where free full texts of all presented communications are available.

Keywords:
diabetes mellitus – oral cavity – caries rate – gingivitis – periodontitis – oral membrane mucous diseases

Sources

1. Balasundram, A., Ponnaiyan, D., Parthasarathy, H.: Diabetes mellitus – a periodontal perspective. SRM J. Dent. Sci., roč. 1, 2010, č. 1, s. 79–85.

2. Correa, F. O. B., Goncalves, D., Figueredo, C. M. S., Bastos, A, S., Gustafsson, A., Orrico, S. R. P.: Effect of periodontal treat-ment on metabolic control, systemic inflammation and cytokines in patients with type 2 diabetes. J. Clin. Periodontol., roč. 37, 2010, č. 1, s. 53–58.

3. Demmer, R. T., Jacobs, D. R., Desvarieux, M.: Periodontal disease and incident type 2 diabetes: results from the First National Health and Nutrition Examination Survey and its epidemiologic follow-up study. Diabetes Care, roč. 31, 2008, č. 7, s. 1373–1379.

4. Demmer, R. T., Desvarieux, M., Holtfreter, B., Jacobs, D. R.: Periodontal status and A1C change: longitudinal results from the study of health in Pomerania (SHIP). Diabetes Care, roč. 33, 2010, č. 5, s. 1037–1043.

5. Dikshit, R. P., Ramadas, K., Hashibe, M., Thomas, G., Somanathan, T.: Association between diabetes mellitus and pre-malignant oral diseases: a cross sectional study in Kerala, India. Int. J. Cancer, roč. 118, 2006, č. 2, s. 453–457.

6. Dušková, J.: Stomatologická onemocnění u diabetu. Praha, Professional Publishing, 2000.

7. Ebersole, J. L., Holt, S. C., Hansard, R., Novak, M. J.: Microbiologic and immunologic characteristics of periodontal disease in Hispanic americans with type 2 diabetes. J. Periodontol., roč. 79, 2008, č. 4, s. 637–646.

8.Engebretson, S. P., Chertog, R., Nichols, A., Hey-Hadavi, J., Celenti, R.: Plasma levels of tumour necrosis factor-alpha in patients with chronic periodontitis and type 2 diabetes. J. Clin. Periodontol., roč. 34, 2007, č. 1, s. 18–24.

9. Engebretson, S. P., Vossughi, F., Hey-Hadavi, J., Emingil, G., Grbic, T.: The influence of diabetes on gingival crevicular fluid beta-glucuronidase and interleukin-8. J. Clin. Periodontol., roč. 33, 2006, č. 11, s. 784–790.

10. Goutzanis, L., Vairaktaris, E., Yapijakis, C., Kavantzas, N., Derka, S.: Diabetes may increase risk for oral cancer through the insulin receptor substrate-1 and focal adhesion kinase pathway. Oral Oncol., roč. 43, 2007, č. 2, s. 165–173.

11. Guggenheimer, J., Moore, P. A., Rossie, K., Myers, D., Mongelluzzo, M. B., Block, H. M.: Insulin-dependent diabetes mellitus and oral soft tissue pathologies: II. Prevalence and characteristics of Candida and candidal lesions. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., roč. 89, 2000, č. 5, s. 570–576.

12. Gurav, A., Jadhav, V.: Periodontitis and risk of diabetes mellitus. J. Diabetes, roč. 3, 2011, č. 1, s. 21–28.

13. Hungund, S., Panseriya, B. J.: Reduction in HbA1c levels following non-surgical periodontal therapy in type-2 diabetic patients with chronic generalized periodontitis: A periodontist’srole. J. Indian. Soc. Periodontol., roč. 16, 2012, č. 1, s. 16–21.

14. Chaffee, B. W., Weston, S. J.: Association between chronic periodontal disease and obesity: a systematic review and meta-analysis. J. Periodontol., roč. 81, 2010, č. 12, s. 1708–1724.

15. Chapple, I. L. C., Genco, R.: Diabetes and periodontal diseases: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. J. Clin. Periodontol., 2013, roč. 40, Suppl. 14, s. 106–112.

16. Choi, Y.-H. McKeown, R. E., Mayer-Davis, E. J., Liese, A. D., Song, K. B.: Association between periodontitis and impaired fasting glucose and diabetes. Diabetes Care, roč. 34, 2011, č. 2, s. 381–386.

17. Javed, F., Romanos, G. E.: Impact of diabetes mellitus and glycemic control on the osseointegration of dental implants: a systematic literature review. J. Periodontol., roč. 80, 2009, č. 11, s. 1719–1730.

18. Kao, C. H., Tsai, S. C., Sun, S. S.: Scintigraphic evidence of poor salivary function in type 2 diabetes. Diabetes Care, roč. 24, 2001, č. 5, s. 952–953.

19. Khader, Y. S., Albashaireh, Z. S. M., Hammad, M. M.: Periodontal status of type 2 diabetics compared with nondiabetics in north Jordan. East. Mediterr. Health J., roč. 14, 2008, č. 3, s. 654–661.

20. Khovidhunkit, S. P., Suwantuntula, T., Thaweboon, S., Mitrirattanakul, S., Chomkhakhai, U.: Xerostomia, hyposalivation, and oral microbiota in type 2 diabetic patients: a preliminary study. J. Med. Assoc. Thai., roč. 92, 2009, č. 9, s. 1220–1228.

21. Lalla, E., Cheng, B., Lal, S., Kaplan, S., Softness, B., Greenberg, E.: Diabetes mellitus promotes periodontal destruction in children. J. Clin. Periodontol., roč. 34, 2007, č. 4, s. 294–298.

22. Lalla, E., Kaplan, S., Chang, S. J., Roth, G. A., Hinckley, K., Greenberg, E.: Periodontal infection profiles in type 1 diabetes. J. Clin. Periodontol., roč. 33, 2006, č. 12, s. 855–862.

23. Lim, L. P., Tay, F. B. K., Sum, C. F., Thai, A. C.: Relationship between markers of metabolic control and inflammation on severity of periodontal disease in patients with diabetes mellitus. J. Clin. Periodontol., roč. 34, 2007, č. 2, s. 118–123.

24. Liu, R., Bal, H. S., Desta, T., Krothapalli, N., Alyassi, M., Luan, Q.: Diabetes enhances periodontal bone loss through enhanced resorption and diminished bone formation. J. Dent. Res., roč. 85, 2006, č. 6, s. 510–514.

25. Löe, H.: Periodontal disease. The sixth complication of diabetes mellitus. Diabetes Care, roč. 16, 1993, č. 1, s. 329–334.

26. Makiura, N., Ojima, M., Kou, Y., Furuta, N., Okahashi, N., Shizukuishi, S.: Relationship of Porphyromonas gingivalis with glycemic level in patients with type 2 diabetes following periodontal treatment. Oral Microbiol. Immunol., roč. 23, 2008, č. 4, s. 348–351.

27. Maskari, A. Y., Al-Maskari, M. Y., Al-Sudairy, S.: Oral manifestations and complications of diabetes mellitus: a review. Sultan Qaboos Univ. Med. J., roč. 11, 2011, č. 2, s. 179–186.

28. Mathur, L. K., Manohar, B., Shankarapillai, R., Pandya, D.: Obesity and periodontitis: A clinical study. J. Indian Soc. Periodontol., roč. 15, 2011, č. 3, s. 240–244.

29. Mealey, B. L., Oates, T. W.: Diabetes mellitus and periodontal diseases. J. Periodontol., roč. 77, 2006, č. 8, s. 1289–1303.

30. Negrato, C. A., Tarzia, O.: Buccal alterations in diabetes mellitus. Diabetol. Metab. Syndr., roč. 2, 2010, č. 3. http://www.dmsjournal.com/content/2/1/3

31. Nesse, W., Linde, A., Abbas, F., Spijkervet, F. K. L., Dijkstra, P. U., de Brabander, E. C., Gerstenbluth, I.: Dose-response relationship between periodontal inflamed surface area and HbA1c in type 2 diabetics. J. Clin. Periodontol., roč. 36, 2009, č. 4, s. 295–300.

32. Olson, J. W., Shernoff, A. F., Tarlow, J. L., Colwell, J. A., Scheetz, J. P., Bingham, S. F.: Dental endosseous implant assessments in a type 2 diabetic population: a prospective study. Int. J. Oral Maxillofac. Implants, roč. 15, 2000. č. 6, s. 811–818.

33. Patel, M. H., Kumar, J. V., Moss, M. E.: Diabetes and tooth loss: an analysis of data from the National Health and Nutrition Examination Survey, 2003–2004. J. Am. Dent. Assoc., roč. 144, 2013, č. 5, s. 478–485.

34. Petrou-Amerikanou, C., Markopoulos, A. K., Belazi, M., Karamitsos, D., Papanayotou, P.: Prevalence of oral lichen planus in diabetes mellitus according to the type of diabetes. Oral Dis., roč. 4, 1998, č. 1, s. 37–40.

35. Rajhans, N. S., Kohad, R. M., Chaudhari, V. G., Mhaske, N. H.: A clinical study of the relationship between diabetes mellitus and periodontal disease. J. Indian Soc. Periodontol., roč. 15, 2011, č. 4, s. 388–392.

36. Salvi, G. E., Carollo-Bittel, B., Lang, N. P.: Effects of diabetes mellitus on periodontal and peri-implant conditions: update on associations and risks. J. Clin. Periodontol., roč. 35, 2008. č. 8, Suppl., s. 398–409.

37. Sandberg, G. E., Wikblad, K. F.: Oral dryness and peripheral neuropathy in subjects with type 2 diabetes. J. Diabetes Complicat., roč. 17, 2003, č. 4, s. 192–198.

38. Saremi, A., Nelson, R. G., Tulloch-Reid, M., Hanson, R. L., Sievers, M .L., Taylor, G. W., Shlossman, M.: Periodontal disease and mortality in type 2 diabetes. Diabetes Care, roč. 28, 2005, č. 1, s. 27–32.

39. Seymour, G. J., Ford, P. J., Cullinan, M. P., Leishman, S., Yamazaki, K.: Relationship between periodontal infections and systemic disease. Clin. Microbiol. Infect., roč. 13, 2007, Suppl. 4, s. 3–10.

40. Soory, M.: Hormone mediation of immune responses in the progression of diabetes, rheumatoid arthritis and periodontal diseases. Curr. Drug Targets Immune Endocr. Metabol. Disord., roč. 2, 2002. č. 1, s. 13–25.

41. Soskolne, W. A., Klinger, A.: The relationship between periodontal diseases and diabetes: an overview. Ann. Periodontol., roč. 6, 2001, č. 1, s. 91–98.

42. Spangler, L., Reid, R. J., Inge, R., Newton, K. M., Hujoel, P., Chaudhari, M., Genco, R. J.: Cross-sectional study of periodontal care and glycosylated hemoglobin in an insured population. Diabetes Care, roč. 33, 2010, č. 8, s. 1753–1758.

43. Stolbová, K., Hahn, A., Benes, B., Andel, M., Treslová, L.: Gustometry of diabetes mellitus patients and obese patients. Int. Tinnitus J., roč. 5, 1999, č. 2, s. 135–140.

44. Sun, W. L., Chen, L., Zhang, S. Z., Wu, Y. M., Ren, Y. Z., Qin, G. M.: Inflammatory cytokines, adiponectin, insulin resistance and metabolic control after periodontal intervention in patients with type 2 diabetes and chronic periodontitis. Intern. Med., roč. 50, 2011, č. 15, s. 1569–1574.

45. Syrjälä, A. M. H., Ylöstalo, P., Niskanen, M. C., Knuuttila, M. L. E.: Role of smoking and HbA1c level in periodontitis among insulin-dependent diabetic patients. J. Clin. Periodontol., roč. 30, 2003, č. 10, s. 871–875.

46. Taylor, G. W.: Bidirectional interrelationships between diabetes and periodontal diseases: an epidemiologic perspective. Ann. Periodontol., roč. 6, 2001, č. 1, s. 99–112.

47. Taylor, J. J., Preshaw, P. M., Lalla, E.: A review of the evidence for pathogenic mechanisms that may link periodontitis and diabetes. J. Clin. Periodontol., roč. 40, 2013, Suppl. 14, s. 113–134.

48. Teeuw, W. J., Gerdes, V. E. A., Loos, B. G.: Effect of periodontal treatment on glycemic control of diabetic patients: a systematic review and meta-analysis. Diabetes Care, roč. 33, 2010, č. 2, s. 421–427.

49. Tsai, C., Hayes, C., Taylor, G. W.: Glycemic control of type 2 diabetes and severe periodontal disease in the US adult population. Community Dent. Oral Epidemiol., roč. 30, 2002, č. 3, s. 182–192.

50. Whiting, D. R., Ikekpeazu, E. L., Weil, C., Shaw, C.: IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res. Clin. Pract., roč. 94, 2011, č. 3, s. 311–321.

51. Zeman, M., Jirák, R.: Alzheimerova choroba a diabetes mellitus typu 2. Neurol. praxi, roč. 13, 2012, č. 2, s. 105–108.

52. Ústav zdravotnických informací a statistiky ČR. Dostupné na http://www.uzis.cz/katalog/zdravotnicka-statistika/pece-nemocne-cukrovkou

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Article was published in

Czech Dental Journal

2014 Issue 5