The Association Study of the Relationship between Fourteen Candidate Gene Polymorphisms and Dispositions to the Alcoholism

Czech version

Authors: O. Šerý; J. Lochman; K. Gláslová ¹; R. Štaif; M. Novotný ¹; V. Kmoch ¹; P. Zvolský ¹
Authors‘ workplace: Laboratoř neurobiologie a molekulární psychiatrie, Laboratoře molekulární fyziologie, Ústav biochemie, Přírodovědecká fakulta MU, Brno ředitel Ústavu biochemie doc. Ing. M. Mandl, CSc. Psychiatrická klinika 1. LF UK a VFN, Praha ; přednosta prof. MUDr. J. Raboch, DrSc. ¹
Published in: Čes. a slov. Psychiat., 105, 2009, No. 4, pp. 153-162.
Category: Original Article

Overview

Predisposition to alcohol dependence is affected by multiple environmental and genetic factors. Modern molecular genetic techniques allow examining specific genes involved in the pathophysiology of complex diseases such as alcohol dependence. Between strategies for susceptibility gene identification are association studies. We carried out the association study of fourteen candidate gene polymorphisms and alcohol dependence. The association study was performed on 847 persons. We found the association between alcohol dependence and genes for COMT, MAO-B, IL6, IL2, LILRA1 and PSG11. All associated genes influence the neurodevelopment of central nervous system. We suppose the relationship between genes involved in the neurodevelopment of CNS and dispositions to the alcohol dependence.

Key words:
alcohol dependence, association study, polymorphism, gene, COMT, IL6, IL2, MAO, DAT1, DRD2.

Sources

1. Arias, A., Feinn, R., Kranzler, H. R.: Association of an Asn40Asp (A118G) polymorphism in the mu-opioid receptor gene with substance dependence: a meta-analysis. Drug Alcohol Depend., 83, 2006, pp. 262-268.

2. Blum, K., Noble, E. P., Sheridan, P. J., Montgomery, A., Ritchie, T., Jagadeeswaran, P., Nogami, H., Briggs, A. H., Cohn, J. B.: Allelic association of human dopamine D2 receptor gene in alcoholism. JAMA, 263, 1990, pp. 2055-2060.

3. Eugen-Olsen, J., Iversen, A. K., Garred, P., Koppelhus, U., Pedersen, C., Benfield, T. L., Sorensen, A. M., Katzenstein, T., Dickmeiss, E., Gerstoft, J., Skinhøj, P., Svejgaard, A., Nielsen, J. O., Hofmann, B.: Heterozygosity for a deletion in the CKR-5 gene leads to prolonged AIDS-free survival and slower CD4 T-cell decline in a cohort of HIV-seropositive individuals. AIDS, 11, 1997, pp. 305-310.

4. Foley, P. F., Loh, E. W., Innes, D. J., Williams, S. M., Tannenberg, A. E., Harper, C. G., Dodd, P. R.: Association studies of neurotransmitter gene polymorphisms in alcoholic Caucasians. Ann. N Y Acad. Sci., 1025, 2004, pp. 39-46.

5. Franke, P., Schwab, S. G., Knapp, M., Gänsicke, M., Delmo, C., Zill, P., Trixler, M., Lichtermann, D., Hallmayer, J., Wildenauer, D. B., Maier, W.: DAT1 gene polymorphism in alcoholism: a family-based association study. Biol. Psychiatry, 45, 1999, pp. 652-654.

6. Garpenstrand, H., Ekblom, J., Forslund, K., Rylander, G., Oreland, L.: Platelet monoamine oxidase activity is related to MAOB intron 13 genotype. J. Neural. Transm., 107, 2000, pp. 523-30.

7. Grandy, D. K., Zhang, Y., Civelli, O.: PCR detection of the TaqA RFLP at the DRD2 locus. Hum. Mol. Genet., 2, 1993, p. 2197.

8. Hoffmann, S. C., Stanley, E. M., Darrin Cox, E., Craighead, N., DiMercurio, B. S., Koziol, D. E., Harlan, D. M., Kirk, A. D., Blair, P. J.: Association of cytokine polymorphic inheritance and in vitro cytokine production in anti-CD3/CD28-stimulated peripheral blood lymphocytes. Transplantation, 72, 2001, pp. 1444-1450.

9. Chiu, Y. F., Liu, S. Y., Tsai, Y. Y.: A comparison in association and linkage genome-wide scans for alcoholism susceptibility genes using single-nucleotide polymorphisms. BMC Genetics, 6, 2005, p. S89.

10. Jönsson, E. G., Goldman, D., Spurlock, G., Gustavsson, J. P., Nielsen, D. A., Linnoila, M., Owen, M. J., Sedvall, G. C.: Tryptophan hydroxylase and catechol-O-methyltransferase gene polymorphisms: relationships to monoamine metabolite concentrations in CSF of healthy volunteers. Eur. Arch. Psychiatry Clin. Neurosci., 247, 1997, pp. 297-302.

11. Kašparovská, J., Hříbková, H., Hloušková, R., Novotný, M., Gláslová, K., Šimek, V., Mikeš, V., Zvolský, P., Šerý, O.: TaqI A polymorfismus genu pro dopaminový receptor D2 a alkoholismus v České republice. Čes. a slov. Psychiat., 99, 2003, pp. 5-9.

12. Köhnke, M. D., Batra, A., Kolb, W., Köhnke, A. M., Lutz, U., Schick, S., Gaertner, I.: Association of the dopamine transporter gene with alcoholism. Alcohol Alcohol., 40, 2005, pp. 339-342.

13. Lu, R. B., Lee, J. F., Ko, H. C., Lin, W. W., Chen, K., Shih, J. C.: No association of the MAOA gene with alcoholism among Han Chinese males in Taiwan. Prog. Neuropsychopharmacol. Biol. Psychiatry, 26, 2002, pp. 457-461.

14. Marcos, M., Pastor, I., González-Sarmiento, R., Laso, F. J.: A new genetic variant involved in genetic susceptibility to alcoholic liver cirrhosis: -330T>G polymorphism of the interleukin-2 gene. Eur. J. Gastroenterol. Hepatol., 20, 2008, pp. 855-859.

15. Parsian, A., Zhang, Z. H.: Human dopamine transporter gene polymorphism (VNTR) and alcoholism. Am. J. Med. Genet., 74, 1997, pp. 480-482.

16. Raber, J., Sorg, O., Horn, T. F., Yu, N., Koob, G. F., Campbell, I. L., Bloom, F. E.: Inflammatory cytokines: putative regulators of neuronal and neuro-endocrine function. Brain Res. Brain Res. Rev., 26, 1998, pp. 320-326.

17. Rigat, B., Hubert, C., Corvol, P., Soubrier, F.: PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1). Nucleic Acids Res., 20, 1992, p. 1433.

18. Russ, A. P., Maerz, W., Ruzicka, V., Stein, U., Gross, W.: Rapid detection of the hypertension-associated Met235—>Thr allele of the human angiotensinogen gene. Hum. Mol. Genet., 2, 1993, pp. 609-610.

19. Shinohara, M., Mizushima, H., Hirano, M., Shioe, K., Nakazawa, M., Hiejima, Y., Ono, Y., Kanba, S.: Eating disorders with binge-eating behaviour are associated with the s allele of the 3’-UTR VNTR polymorphism of the dopamine transporter gene. J. Psychiatry Neurosci., 29, 2004, pp. 134-137.

20. Šerý, O., Hladilová, R., Novotný, M., Znojil, V., Zvolský, P.: Polymorfismus genu pro IL-6 má vztah k dispozicím k závislosti na alkoholu. Čes. a slov. Psychiat., 99, 2003, s. 185-188.

21. Šerý, O., Lochman, J., Častulík, L., Šťastný, F., Přikryl, R., Češková, E.: Polymorfismus genu pro OPMR1 má vztah ke schizofrenii: nový kandidátní gen. Čes. a slov. Psychiat., 105, 2009 (v tisku).

22. Šerý, O., Lochman, J., Zvolský, P., Hlinomazová, Z., Novotný, M.: Porucha barvocitu u alkoholiků a její souvislost s polymorfizmem genu pro BDNF. Čes. a slov. Psychiat., 104, 2008, s. 115-119.

23. Šerý, O., Mikes, V., Pitelová, R., Znojil, V., Zvolský, P.: The association between high-activity COMT allele and alcoholism. Neuro Endocrinol Lett., 27, 2006, pp. 231-235.

24. Šerý, O., Theirner, P., Hladilová, R., Štaif, R., Balaštiková, B., Drtílková, I.: Geny pro Il-6 a DRD2 souvisejí s hyperkinetickou poruchou. Čes. a slov. Psychiat., 99, 2003, s. 404-409.

25. Tsai, S. J., Liao, D. L., Yu, Y. W., Chen, T. J., Wu, H. C., Lin, C. H., Cheng, C. Y., Hong, C. J.: A study of the association of (Val66Met) polymorphism in the brain-derived neurotrophic factor gene with alcohol dependence and extreme violence in Chinese males. Neurosci. Lett., 381, 2005, pp. 340-343.

26. Wernicke, C., Smolka, M., Gallinat, J., Winterer, G., Schmidt, L. G., Rommelspacher, H.: Evidence for the importance of the human dopamine transporter gene for withdrawal symptomatology of alcoholics in a German population. Neurosci. Lett., 333, 2002, pp. 45-48.

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Article was published in

Czech and Slovak Psychiatry

2009 Issue 4