Neurobiology of ADHD
Authors:
O. Šerý; R. Štaif; Didden W.l
Authors‘ workplace:
Laboratoř neurobiologie a molekulární psychiatrie, Ústav biochemie, Přírodovědecká fakulta MU, Brno
vedoucí ústavu prof. RNDr. V. Mikeš, CSc.
GHC Research Institute, Houston, TX, USA
; ředitel ústavu prof. W. Didden, M. D., Ph. D.
1
Published in:
Čes. a slov. Psychiat., 103, 2007, No. 1, pp. 28-46.
Category:
Comprehensive Reports
Overview
Attention-deficit hyperactivity disorder (ADHD) belongs to common causes of psychiatric treatment in childhood. Risk factors of the pathogenesis are not only genetic factors, but also non-genetic ones such as low weight at birth, perinatal hypoxia and influence of toxic substances during the prenatal period. The causes of the disorder have been thoroughly investigated using the neuroimaging and molecular biology methods in the past ten years. It was found that biological parents and relatives with ADHD have much higher percentage of ADHD symptoms in their offsprings. Obviously, the results of twin studies have brought the evidence of the disorder’s heritability. During the past few years many molecular-biology studies have appeared, which are focused on the research of influence of so-called candidate genes in the pathogenesis of ADHD. Our review summarises the results of these studies.
Key words:
ADHD, hyperkinetic disorder, association study, polymorphism, gene, DRD2, DRD4, COMT, DBH, DAT1, NET1, MAO, IL-6
Labels
Addictology Paediatric psychiatry PsychiatryArticle was published in
Czech and Slovak Psychiatry
2007 Issue 1
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