Polymorphism of the IL-6 Geneis in the Relationship with the Disposition to the Alcohol Dependence
Authors:
O. Šerý 1; R. Hladilová 1; M. Novotný 2; V. Znojil 3; P. Zvolský 2
Authors‘ workplace:
Laboratoř neurobiologie a molekulární psychiatrie, Katedra srovnávací fyziologie živočichů a obecné zoologie, vedoucí katedry prof. RNDr. V. Šimek, CSc. 1 Psychiatrická klinika 1. LF, UK a VFN, Praha, přednosta kliniky prof. MUDr. J. Raboch, DrSc. 2 Ústav
3
Published in:
Čes. a slov. Psychiat., , 2003, No. 4, pp. 185-188.
Category:
Overview
Cytokines play an important role in the CNS in the modulations of dopaminergic, serotonergic,noradrenergic and cholinergic systems. Interleukin-6 (IL-6) is the cytokine released from astrocytes,microglia and neurons in physiological and some pathologic conditions. IL-6 has neuromodulatingeffect in dopaminergic and serotonergic systems of the brain. Moreover, IL-6 influencessurvival of dopaminergic neurons, neurite outgrowth, and glial differentiation in the developingneural tissues. From this point of view, the gene for IL-6 is a possible candidate gene for thedisposition to the alcohol dependence. We investigated the relationship between the G/C -174polymorphism of the IL-6 gene and alcohol dependence in 281 alcoholics and 242 control subjects.The significant difference in G allele frequency between alcoholic group (0,52) and control group(0,59) was found (p
Key words:
alcoholism, interleukin-6, association study, polymorphism.
Labels
Addictology Paediatric psychiatry PsychiatryArticle was published in
Czech and Slovak Psychiatry
2003 Issue 4
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