Treatment of SSRI in the Practice of Psychiatric Ambulances in the CzechRepublic – Open, Non-intervention Six-month Study with Sertraline Hydrochloride (Zoloft®)

Overview

The submitted results summarize data assembled in a non-intervention study of patients treatedwith sertraline hydrochloride (Zoloft®) which lasted six months and was implemented within theframework of standard psychiatric ambulatory care. From out-patient psychiatrists a total of 3382forms were recovered and subsequently processed. There were twice as many females as males.Most frequently treatment was indicated on account of depressive disorders of different intensityand on account of mixed anxiety depressive disorders. In 50% the preparation was administredduring the first episode and in 30% on account of the repeated occurrence of the primary disorder.The severity of the mental disorder was according to CGI (item 1) in 51% patients mediumintense, 25% patients were seriously and 17% slightly sick. Roughly 70% patients were givena dose of 50 mg per day and 24% 100 mg sertraline hydrochloride per day. The tolerance oftreatment was demonstrated by the low incidence of undesirable effects which were recorded in8.5% of the treated patients and receded without sequelae in 94% and no death was recorded inconjunction with treatment. Treatment was discontinued early in 12% of the cases. In the CGIevaluation (item 2) 42% patients were described as markedly improved and another 44% as greatlyimproved. From the assembled data ensues that treatment with sertraline hydrochloride, usingcommon doses, was effective in the majority of patients and the general profile of toleranceindicates its satisfactory tolerance by patients.

Key words:
non-interventional observation study, practical application, depressive disorder, sertralinehydrochloride