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(Meth)akrylátové kopolymery typu Eudragit® v technologii perorálních tablet


: Martina Naiserová 1;  Kateřina Kubová 1;  Jakub Vysloužil 1;  Jurga Bernatoniene 2;  Iosif Brokalakis 1;  David Vetchý 1
: Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno 1;  Department of Drug Technology and Social Pharmacy, Faculty of Pharmacy, Lithuanian University of Health Sciences, Kaunas, Lithuania 2
: Čes. slov. Farm., 2019; 68, 183-197
: Rewiev article

Přehledový článek se zaměřuje na charakterizaci (meth)akrylátových kopolymerů – Eudragitů®, popis jejich chování při tepelném ošetření, možné interakce mezi kationtovými a aniontovými polymery, inkompatibility související s Eudragity® a na jejich využití v oblasti farmaceutické technologie perorálních tablet. V přehledu jsou rozděleny na rozpustné, nerozpustné a kombinaci těchto dvou typů. Právě kombinací rozpustného a nerozpustného poly(meth)akrylátu byl získán nový typ polymeru, Eudragit® FL. V technologii perorálních tablet se Eudragity® hojně využívají v matricových tabletách, a to samostatně nebo i v kombinacích, kde zajišťují zejména prodloužené uvolňování léčiva. V menší míře se využívají v gastroretentivních systémech. Naopak velký význam mají Eudragity® v technologii potahovaných tablet, kde tyto enterosolventní polymery zajišťují specifické směřování léčiva do určitých částí trávicího traktu, zejména do tenkého střeva nebo kolonu. Jsou zde zmíněny důležité systémy jako CODESTM a MMX® technologie. V neposlední řadě je uvedena přehledová tabulka zahrnující aktuálně dostupné perorální léčivé přípravky na českém trhu, u kterých byl jako filmotvorná látka využit některý z Eudragitů®.

Klíčová slova:

Eudragit® – matricové tablety – flotující tablety – potahované tablety – acidorezistentní tablety – burst efekt – prodloužené uvolňování léčiva – přívod léčiva do kolonu


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