Extruze tavenin
Authors:
Jana Šalandová 1,2; Miloslava Rabišková 1
Authors‘ workplace:
Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno
Published in:
Čes. slov. Farm., 2012; 61, 87-92
Category:
Review Articles
Overview
Extruze tavenin, metoda původem z průmyslu plastů, se stává v současnosti velice zajímavou technologií také ve farmacii. Počet špatně rozpustných léčiv s nízkou biologickou dostupností stále stoupá. Většina organických léčiv vykazuje polymorfii. Spolu s využitím vhodných nosných a dalších farmaceutických pomocných látek představuje extruze tavenin zajímavou možnost, jak zvýšit rozpustnost špatně rozpustných léčiv nebo zabránit vzniku nežádoucích polymorfů a jak zlepšit biologickou dostupnost problematických léčiv. Extruzi tavenin lze využít také při formování lékových forem s řízeným uvolňováním léčiv, např. pelet nebo filmů. Je to relativně levná, účinná a reprodukovatelná technologie bez použití rozpouštědel, která je šetrná k léčivům. Článek je přehledem možné využitelnosti této moderní technologie ve farmacii.
Klíčová slova:
extruze tavenin, zařízení, farmaceutické pomocné látky, pelety, filmy
Sources
1. Brabander C. D., Vervaet C., Remon J. P.: Development and evaluation of sustained release mini-matrices prepared via hot melt extrusion. J. Control Release. 2003; 89, 235–247.
2. Chokshi R., Zia H.: Hot-melt extrusion technique: A review. Iranian Journal of Pharmaceutical Research. 2004; 3, 3–16.
3. Crowley M. M., Zhang F., Repka M. A., Thumma S., Upadhye S. B., Battu S. K., McGinity J. W., Martin C.: Pharmaceutical applications of hot-melt extrusion: Part I. Drug. Dev. and Ind. Pharm. 2007; 33, 909–926.
4. Prodduturi S., Urman K. L., Otaigbe J. U., Repka M. A. Stabilization of hot-melt extrusion formulations containing solid solutions using polymer blends. AAPS PharmSciTech. 2007; 8(2), 1–10.
5. Liu X., Lu M., Guo Z., Huang L., Feng X., Wu C.: Improving the chemical stability of amorphous solid dispersion with cocrystal technique by hot melt extrusion. Pharm. Res. 2011; 29(3), 806–817.
6. Abu-Diak O. A., Jones D. S., Andrews G. P.: Understanding the performance of melt-extruded poly(etylene oxide)-bicalutamide solid dispersions: Characterisation of microstructural properties using thermal, spectroscopic and drug release methods. J. Pharm. Sci. 2012; 101(1), 200–213.
7. Nagy Z. K., Balogh A., Vajna B., Farkas A., Patyi G., Kramarics A., Marosi G.: Comparison of electrospun and extruded soluplus® -based solid dosage forms of improved dissolution. J. Pharm. Sci. 2012; 101(1), 322–332.
8. Karl M., Djuric D., Kolter K.: Pharmaceutical excipients for hot-melt extrusion. Pharm. Tech. Europe 2011; 35, 74–82.
9. Feng J., Xu L., Gao R., Luo Y., Tang X.: Evaluation of polymer carriers with the regards to the bioavailability enhancement of bifendate solid dispersions prepared by hot-melt extrusion. Drug Dev. Ind. Pharm. 2011; 1–9.
10. Ghosh I., Snyder J., Vippagunta R., Alvine M., Vakil R., Tong W., Vippagunta S.: Comparison of HPMC based polymers performance as carriers for manufacture of solid dispersions using melt extruder. Int. J. Pharm. 2011; 419, 12–19.
11. Hasa D., Perissutti B., Grassi M., Zacchigna M., Pagotto M., Lenaz D., Kleinebudde P., Voinovich D.: Melt extuded helical waxy matrices as a new sustained drug delivery system. E. J. Pharm. Biopharm. 2011; 79, 592–600.
12. Kanaujia P., Lau G., NG W. K., Widjaja E., Hanefeld A., Fischbach M., Maio M., Tan R. B. H.: Nanoparticle formation and growth during in vitro dissolution of ketoconazole solid dispersion. J. Pharm. Sci. 2011; 100(7), 2876–2885.
13. Brittain H.G.: Polymorphism in pharmaceutical solids. Informa Healthcare USA, Inc., New York 1999.
14. Chieng N., Rades T., Aaltonen J.: An overview of recent studies on the analysis of pharmaceutical polymorphs. J. Pharm. Biomed. Anal. 2011; 55, 618–644.
15. Andrews G. P., Jones D. S. et al.: Hot melt extrusion: An emerging drug delivery technology. Pharmaceutical Technology Europe. 2009; 21, 24–27.
16. Kolter K., Karl M., Nalawade S., Rottmann N. Hot-melt extusion with BASF pharma polymers, 2nd edition. 2011.
17. Shuwisitkul D.: Biodegradable implants with different drug release profiles. Bangkok 2011, Dissertation, page 29.
18. Repka M. A., Majumdar S., Battu S. K., Srirangam R., Upajdye S. B.: Applications of hot-melt extrusion for drug delivery. Expert Opin. Drug Deliv. 2008; 5(12), 1357–1376.
19. Rabišková M.: Peletizace tavenin a kapalin. Čes. slov. Farm. 2011; 60(2), 54–60.
20. Jijun F., Lishuang X., Xiaoguang T., Min S., Mingming Z., Haibing H., Xing T.: The inhibition effect of high storage temperature on the recrystallization rate during dissolution of nimodipine-kollidon VA64 solid dispersion (NM-SD) prepared by hot-melt extrusion. J. Pharm. Sci. 2011; 100(5), 1643–1647.
21. Mahnaj T., Ahmed A. U., Plakogiannis F. M.: Evaluating the efficacy of a group of nontraditional plasticizers on the glass transition temperature of ethyl cellulose polymer. Drug Dev. Ind. Pharm. 2011; 37(3), 342–350.
22. Roblegg E., Jäger E., Hodzic A., Koscher G., Mohr S., Zimmer A., Khinast J. Development of sustained-release lipophilic calcium stearate pellets via hot melt extrusion. Eur. J. Pharm. Biopharm. 2011; 79, 635–645.
23. Liu J., Zhang F., McGinity J. W.: properties of lipophilic matrix tablets containing phenylpropanolamine hydrochloride prepared by hot-melt extrusion. Eur. J. of Pharm. Biopharm. 2001; 52, 181–190.
24. Maclean J., Medina C., Daurio D., Alvarez-Nunez F., Jona J., Munson E., Nagapudi K.: Manufacture and performance evaluation of a stable amorphous complex of an acidic drug molecule and neusilin. J. Pharm. Sci. 2011; 100(8), 3332–3344.
25. Maru S. M., Matas M., Kelly A., Paradkar A.: Characterization of thermal and rheological properties of zidovudine, lamivudine and plasticizer blends with ethyl cellulose to assess their suitability for hot melt extrusion. Eur. J. Pharm. Sci. 2011; 44, 471–478.
26. Repka M. A., Battu S. K., Upadhye S. B., Thumma S., Crowley M. M., Zhang F., Martin C., McGinity J. W.: Pharmaceutical applications of hot-melt extrusion: Part II. Drug Dev. Ind. Pharm. 2007; 33, 1043–1057.
27. Case Ch. C. Melt pelletization. In: Ghebre-Sellasie I. and Martin Ch. eds Pharmaceutical extrusion technology, 1st ed. New York and Basel: Marcel Dekker Inc. 2003.
28. Bialleck S., Rein H.: Preparation of starch-based pellets by hot-melt extrusion. Eur. J. Pharm. Biopharm. 2011; 79, 440–448.
29. Schilling S. U., McGinity J. W.: Novel application of hot-melt extrusion for the preparation of monolithic matrices containing enteric-coated particles. Int. J. Pharm. 2010; 400, 24–31.
30. Shajahan A., Chandevar A. V., Jaiswal S. B.: A flexible technology for modified-release drugs: Multiple-unit pellets system (MUPS). J. Control Release. 2010; 147, 2–16.
31. Maniruzzaman M., Boateng J. S., Bonnefille M., Aranyos A., Mitchell J. C., Douroumis D.: Taste masking of paracetamol by hot melt extrusion: an in vitro and in vivo evaluation. Eur. J. Pharm. Biopharm. 2012;80(2), 433–442.
Labels
Pharmacy Clinical pharmacologyArticle was published in
Czech and Slovak Pharmacy
2012 Issue 3
Most read in this issue
- Fenotypizace enzymů podílejících se na metabolismu léčiv
- Extruze tavenin
- Modulácia leukotriénovej cesty – potenciálne ciele
- Mikrobiálne sekundárne metabolity ako inhibítory farmaceuticky významných oxidoreduktáz a transferáz