Weibull Equation and Dissolution Kinetics

Czech version

Authors: Z. Zatloukal
Authors‘ workplace: Katedra farmaceutické technologie Farmaceutické fakulty Univerzity Karlovy, Hradec Králové
Published in: Čes. slov. Farm., 2004; , 332-335
Category:

Overview

On modelling the kinetics of dissolution, two variants of Weibull equation in a two-parameter ortree-parameter form are used, the estimations of their parameters not being quite comparable. Theintroductory part of the paper sums up four variants of the equation and chracterized theirrelationship to granulometric Rosin–Rammler–Sperling equation. The kinetics of liberation ofpilocarpinium chloride from lyophilized lamellae with graded amounts of hydroxypropylmethylcelluloseis expressed by the above-mentioned equations and their parameters are compared. Theconclusions generally discusses the usability of equations and their correct interperetation inmodelling dissolution of active ingrediens from dosage forms.

Key words:
Weibull equation – dissolution kinetics – hydroxypropylmethylcellulose –pilocarpinium chloride

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