HPLC Determination of Diperodon Enantiomers in Blood Serum by Using TeicoplaninChiral Stationary Phase

Czech version

Authors: K. Hroboňová; J. Lehotay; J. Čižmárik ¹
Authors‘ workplace: Katedra analytickej chémie Fakulty chemickej a potravinárskej chémie Slovenskej technickej univerzity, Bratislava 1Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava
Published in: Čes. slov. Farm., 2004; , 225-227
Category:

Overview

The chiral stationary phase on the base of teicoplanin and the polar-organic mobile phase methanol/acetonitrile/acetic acid/triethylamine 45/55/0.3/0.2 was used for the separation of diperodonenantiomers. The developed method was suitable to determine the enantiomers in blood serum upto 0.5 µg/ml. The degradation of diperodon enantiomers was studied in serum by an in vitro methodand the experimental rate constants were determined.

Key words:
HPLC – teicoplanin – enantiomers – diperodon – enzymatic hydrolysis – rate constants

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