Statistical Aspects of Drug Dosing in Random Powder Mixtures

Overview

The precision of dosing of powder drugs in piece dosage forms can be theoretically forecast by meansof statistical principles of variability of random mixtures, the use of which for this purpose has beentraditionally examined. The present critical review of the literature of the subject is primarilyfocused on random mixing of powder mixtures, their homogenity, volume dosing, and the use ofa correlogram in the examination of nonrandom and segregated mixtures. The knowledge is usefulboth for the selection of a suitable particle size and for the verification of suitability of the employedparameters of mixing and the technological processing of the obtained mixture.

Key words:
powders – random mixture – homogenity – segregation – correlogram