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The in vitro Reactivation of O-Isopropylmethylfluorophosphonate – Inhibited Acetylcholinesteraseby Bisquaternary Oxime HS-6


Authors: K. Kuča;  J. Cabal
Authors‘ workplace: Katedra toxikologie Vojenské lékařské akademie Jana Evangelisty Purkyně, Hradec Králové
Published in: Čes. slov. Farm., 2004; , 93-95
Category:

Overview

The ability of the oxime HS-6 [1-(4-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium)-2--oxa-propane dichloride] to reactive in vitro the enzyme acetylcholinesterase inhibited by the nerveagent sarin [O-isopropylmethylfluorophosphonate] was evaluated. The reactivators 2-PAM [2-hydroxyiminomethyl-1-methylpyridinium chloride], toxogonin [1,3-bis(4-hydroxyiminomethylpyridinium)-2-oxa-propane dichloride] and H-oxime HI-6 [1-(2-hydroxyiminomethylpyridinium)--3-(4-carbamoylpyridinium)-2-oxa-propane dichloride] were chosen for comparison. The oxime HS-6was an effective reactivator of sarin-inhibited AChE. It is not as effective as the H-oxime HI-6, butit is better than 2-PAM and obidoxime.

Key words:
acetylcholinesterase – sarin – HS-6 – HI-6 – obidoxime – 2-PAM – in vitro

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Labels
Pharmacy Clinical pharmacology

Article was published in

Czech and Slovak Pharmacy


2004 Issue 2

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