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Antimycobacterial Effects of Pyrrolidinoethylesters of Alkoxysubstituted Phenylcarbamic Acids


Authors: K. Waisser;  J. Čižmárik;  K. Dražková;  J. Kaustová
Authors‘ workplace: Katedra anorganické a organické chemie Farmaceutické fakulty Univerzity Karlovy, Hradec Králové Katedra farmaceutické chemie Farmaceutické fakulty Univerzity Komenského, Bratislava Krajská hygienická stanice, Ostrava
Published in: Čes. slov. Farm., 2002; , 140-144
Category:

Overview

Pyrrolidinoethylesters of alkoxysubstituted phenylcarbamic acids, formerly investigated for local anaesthetic activity, can be considered to be potential antituberculotics. They are effective in nitro against Mycobacterium tuberculosis, Mycobacterium kansasii, and Mycobacterium avium. Their effect increases with the length of the alkyl chain in the alkoxy group bound to the phenyl. The influence of the position of the alkoxyl chain on the phenyl is not too marked, but it seems to decrease in the series m-, p-, o-.

Key words:
esters of phenylcarbamic acid-mycobacterium-antituberculotics -tuberculostatics - QSAR

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Labels
Pharmacy Clinical pharmacology

Article was published in

Czech and Slovak Pharmacy


2002 Issue 3

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