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Study of Local AnestheticsPart 154: Study of Micelization of the Homologs of Heptacainium Chloride


Authors: F. Andriamainty;  RIKJ. Čižmá
Authors‘ workplace: Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava
Published in: Čes. slov. Farm., 2001; , 153-155
Category:

Overview

We have studied the critical micellar concentration (c.m.c.) of the homologs of the local anestheticheptacaine in the medium 0.1 mol/l NaCl, employing spectrophotometry in the UV region of thespectrum at T=21 °C and pH » 4.5Œ5.0. On the basis of our experimental results, it is assumed thatin the homologous series of amphiphilic compounds the quasi-parabolic dependence of biologicalpotencies on the length of their hydrophobic substituent (—cut-offit effect) could be caused by c.m.c.

Key words:
local anesthetic - heptacaine - critical micellar concentration (c.m.c.)

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Pharmacy Clinical pharmacology
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