Studies of Physico-Chemical Properties of Compounds from the Group of 1-(4-Phenyl-1--piperazinyl)-3-methoxy-2-propylesters of 2-,3-Alkoxyphenylcarbamic Acids

Czech version

Authors: E. Sedlárová; J. Čižmárik; Ľ. Búčiová
Authors‘ workplace: Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava
Published in: Čes. slov. Farm., 1999; , 170-174
Category:

Overview

The physico-chemical parameters (surface tension, dissociation constants, experimental partitioncoefficient, RF and RM values by means of thin-layer chromatography, logarithm of the capacityfactor with the help of HPLC) of 8 newly synthetic drugs from the group of 1-(4-phehyl-1-piperazi-nyl)-3-methoxy-2-propylesters of 2-, 3-alkoxyphenylcarbamic acids with assumed local anaesthetic,anti-arrhythmic, and antiulcerous activity were determined. The structure – physico-chemicalproperties relationship was investigated by means of QSAR.

Key words:
1-(4-phenyl-1-piperazinyl)-3-methoxy-2-propylesters of 2-, 3-alkoxyphenylcarbamicacids – physico-chemical properties – correlations

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Article was published in

Czech and Slovak Pharmacy

1999 Issue 4