Automatic Retinal Oxymetry in Patients with Diabetic Retinopathy
Authors:
I. Šínová; O. Chrapek; P. Mlčák; J. Řehák; M. Karhanová; M. Šín
Authors‘ workplace:
Oční klinika FN a UP, Olomouc
přednosta prof. MUDr. Jiří Řehák, CSc., FEBO
Published in:
Čes. a slov. Oftal., 72, 2016, No. 5, p. 182-186
Category:
Original Article
Overview
Aim:
To determine if oxygen saturation in retinal vessels depends on the degree of diabetic retinopathy.
Material and methods:
A prospective study comparing values of oxygen saturation in retinal arteries, veins, and arterio – venous (A-V) difference in healthy persons and in patients with diagnosed diabetes. The study included 114 eyes of 76 patients with diagnosed diabetes, and 57 eyes of 57 patients without diabetes as a control group.
Results:
The average retinal arterial saturation in patients without diabetes was 96.5 ± 2.6 %, and increased in patients with severe non-proliferative or proliferative diabetic retinopathy to 100.5 ± 5.6 %. The average venous saturation in patients without diabetes was 62.3 ± 7.4 % and increased to 74,0 ± 7.2 % in patients with severe non-proliferative diabetic retinopathy.
Conclusion:
In patients with diabetic retinopathy, we confirmed the increase of hemoglobin oxygen saturation as in the arterial as in the venous blood in retinal vessels; and significant decrease of arterio-venous difference according to the severity of diabetic involvement was confirmed as well.
Key words:
automatic retinal oxymetry, diabetic retinopathy, oxygen saturation, Oxymap
Sources
1. Ashton N: Vascular basement membrane changes in diabetic retinopathy. Montgomery lecture 1973. Br J Ophthalmol, 58; 1974: 344–366.
2. Boguszaková J, Doležalová J, Gajdošíková Z: Diabetická makulopatie. Čes Oftalmol, 50; 1994: Suppl. S12–8.
3. Cogan DG, Kuwabara T: Capillary Shunts in the Pathogenesis of Diabetic Retinopathy. Diabetes, 12; 1963: 293–300.
4. Feke GT, Tagawa H, Deupree DM et al.: Blood flow in the normal human retina. Invest Ophthalmol Vis Sci, 30(1); 1989: 58–65.
5. Graham JJ., Ryall RG, & Wise PH: Glycosylated haemoglobin and relative polycythaemia in diabetes mellitus. Diabetologia, 18(3); 1980: 205–207.
6. Hammer M, Vilser W, Riemer T et al.: Diabetic patients with retinopathy show increased retinal venous oxygen saturation. Graefes Arch Clin Exp Ophthalmol, 247(8); 2009: 1025–30.
7. Hardarson SH, Harris A, Karlsson RA et al.: Automatic retinal oximetry. Invest Ophthalmol Vis Sci., 47(11); 2006: 5011–6.
8. Hardarson SH, Basit S, Jonsdottir TE et al.: Oxygen saturation in human retinal vessels is higher in dark than in light. Invest Ophthalmol Vis Sci., 50(5); 2009: 2308–11.
9. Hardarson SH, Stefánsson E.: Retinal oxygen saturation is altered in diabetic retinopathy. Br J Ophthalmol., 96(4); 2012: 560–3.
10. Jørgensen CM, Hardarson SH, Bek T.: The oxygen saturation in retinal vessels from diabetic patients depends on the severity and type of vision-threatening retinopathy. Acta Ophthalmol, 92(1); 2014: 34–39.
11. Jørgensen CM, Bek T.: Increasing oxygen saturation in larger retinal vessels after photocoagulation for diabetic retinopathy. Invest Ophthalmol Vis Sci, 55(8); 2014: 5365–5369.
12. Kennedy L, Baynes JW.: Non-enzymatic glycosylation and the chronic complications of diabetes: an overview. Diabetologia, 26(2); 1984: 93–98.
13. Kohner EM.: Diabetic retinopathy. BMJ, 307; 1993: 1195–1199.
14. Kuwabara T, Cogan DG.: Retinal vascular patterns. VI. Mural cells of the retinal capillaries. Arch Ophthalmol, 69; 1963: 492–502.
15. Linsenmeier RA, Braun RD, McRipley MA et al.: Retinal hypoxia in long-term diabetic cats. Invest Ophthalmol Vis Sci, 39(9); 1998: 1647–57.
16. Roy S, Ha J, Trudeau K, Beglova E.: Vascular Basement Membrane Thickening in Diabetic Retinopathy. Curr Eye Res, 35; 2010: 1045–1056.
17. Schweitzer D, Leistritz L, Hammer M et al.: Calibration-free measurement of the oxygen saturation in human retinal vessels. Ophthalmic Technologies V. Proc SPI, 2393; 1995: 210–218.
18. Sosna T., Švancarová R., Netuková M.: Diabetická retinopatie – rizikové faktory, prevence a terapie. Čes a slov Oftal, 66(5); 2010: 195–203.
19. Šín M., Šínová I., Chrapek O. et al.: The effect of pars plan vitrectomy on oxygen saturation in retinal vessels - a pilot study. Acta Ophthalmol, 92(4); 2014: 328–332.
20. Šín M., Chrapek O., Šínová I. et al.: The effect of pars plana vitrectomy and nuclear cataract on oxygen saturation in retinal vessels, diabetic and non-diabetic patients compared. Acta Ophthalmol, 94(1); 2016: 41–47.
21. Traustason S, Jensen AS, Arvidsson HS et al.: Retinal oxygen saturation in patients with systemic hypoxemia. Invest Ophthalmol Vis Sci, 52; 2011: 5064–5067.
22. Wilkinson CP, Ferris FL, Klein RE et al.: Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology, 110(9); 2003: 1677–1682.
Labels
OphthalmologyArticle was published in
Czech and Slovak Ophthalmology
2016 Issue 5
Most read in this issue
- Blepharophimosis-ptosis-epicanthus inversus syndrome
- Iris melanoma in a child
- Preimplantation genetic diagnosis and monogenic inherited eye diseases
- The Tear Osmolarity of PATIENTS with Lagophthalmos