Eye and Inflammatory Bowel Diseases
Authors:
M. Brichová; prof. MUDr. Jarmila Heissigerová, Ph.D., MBA; P. Svozílková; J. Dvořák; D. Jeníčková; E. Říhová
Authors‘ workplace:
Oční klinika, 1. lékařská fakulta, Univerzita Karlova v Praze a Všeobecná fakultní nemocnice, Praha, přednostka doc. MUDr. Bohdana Kalvodová, CSc.
Published in:
Čes. a slov. Oftal., 67, 2011, No. 3, p. 92-96
Category:
Original Article
Overview
Aim:
To point out the wide range of ocular features of inflammatory bowel diseases (IBD), focusing on uveitis.
Methods:
A retrospective study.
Results:
In the Centre for diagnosis and therapy of uveitis of our Ophthalmology Department, we have in years 2003–2010 followed in total 18 patients with intraocular inflammation associated with IBD: anterior uveitis (14), vasculitis (1), panuveitis (1), infectious uveitis as a secondary complication of systemic immunosuppressive therapy (2). The most often diagnosis was mild to moderate recurrent acute anterior uveitis. We have noticed more severe course of uveitis in patients with the HLA B27 positivity. Part of this paper consists of an overview of other ocular manifestations of IBD and current available therapeutical strategies.
Conclusion:
Ocular manifestations of IBD can be a valuable signal of the activity of the primary disease. The knowledge of the ocular manifestations of these systemic diseases and of possible complications is required for successful interdisciplinary care of patients with IBD. While local treatment is fully in hands of an ophthalmologist, the form and extent of the systemic treatment is necessary to coordinate with gastroenterologists.
Key words:
uveitis, inflammatory bowel disease, ulcerative colitis, Crohn’s disease
Sources
1. Banares, A., Jover, JA., Fernandez-Guterrez, B. et al.: Patterns of uveitis as a guide in making rheumatologic and immunologic diagnosis. Arthritis Rheum, 1997; 40:358-370.
2. Crohn, BB.: Ocular lesions complicating ulcerative colitis. Amer J Med Sci, 1925; 169: 260–267.
3. Ernst, BB., Lowder, CZ., Meisler, DM. et al.: Posterior segment manifestations of inflammatory bowel disease. Ophthalmology, 1991; 98: 1272–1280.
4. Ghanchi, FD., Rembacken, BJ.: Inflammatory bowel disease and the eye. Surv Ophthalmol, 2003; 48: 663–676.
5. Hofley, P., Roarty, J., McGinnity, G. et al.: Asymptomatic uveitis in children with chronic inflammatory bowel diseases. J. Pediatr. Gastoenterol Nutr, 1993; 17: 397–400.
6. Hopkana, DJ., Horan, E., Buton, IL. et al.: Ocular disorders in a series of 332 patients with Crohn’s disease. Br J Ophthalmol, 1974; 58: 732–737.
7. Jabs, DA., Nussenblatt, RB., Atmaca, LS. et al.: Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop. Am J Ophthalmol, 2005; 140: 509–516.
8. Kaufmann, HJ., Taubin, HL.: Nonsteroidal anti-inflammatory drugs activate quiescent inflammatory bowel disease. Ann Intern Med, 1987; 107: 513–516.
9. Knox, DL., Schachat, APOD., Mustoen, E.: Primary, secondary and coincidental ocular complications of Crohn’s disease. Ophthalmology, 1984; 91: 163–173.
10. Knox, DL., Snip, RC., Stark, WJ.: The keratopathy of Crohn’s disease. Am J Ophthalmol, 1980; 90: 862–865.
11. Leibovitch, I, Galanopoulos, A, Selva, D.: Suppurative granulomatous myositis of an extra-ocular muscle in Crohnęs disease. Am J Gatroenterol, 2005; 100: 2136–2137.
12. Lyons, JL., Rosenbaum, JT.: Uveitis associated with inflammatory bowel disease compared with uveitis associated with spodyloarthropathy. Arch Ophthalmol, 1997; 115: 61–64.
13. McCannel, CA., Holland, GN., Helm, CJ. et al.: Causes of uveitis in the general practice of ophthalmology. UCLA Community-Based Uveitis Study Group. Am J Ophthalmol, 1996; 121: 35–46.
14. Říhová, E., Havlíková, M., Michalová, K., Strasmajer, V.: Akutní přední uveitida, systémové choroby a HLA B27. Čes a Slov Oftal, 1997; 53: 80–87.
15. Salmon, JF., Wright, JP., Murray, AD.: Ocular inflammation in Crohn’s disease. Ophthalmology, 1991; 98: 480–4.
16. Sartor, RB.: Pathogenesis and immune mechanisms of chronic inflammatory bowel disease. Am J Gastroenterol, 1997; 92: 5–11.
17. Schode-Lesnick, B., Brandt, LJ.: Selected rheumatologic and dermatologic manifestations of inflammatory bowel disease. Am J Gastroenterol, 1988; 83: 216–223.
18. Soukiasian, SH., Foster, CS., Raizman, MB.: Treatment strategies for scleritis and uveitis associated with inflammatory bowel disease. Am J Ophthalmol, 1994; 118: 601–611.
19. Tailor, SRJ., McCluckey, P., Lightman, S.: The ocular manifestations of inflammatory bowel disease. Curr Opin Ophthalmol, 2006; 17: 538–544.
20. Veloso, FT., Carvalho, J., Margo, F.: Immune-related systemic manifestations of inflammatory bowel disease. A prospective study of 792 patients. J Clin Gastroenterol, 1996; 23: 29–34.
21. Verbraak, FD., Schreinemachers, MC., Miller, A. et al.: Prevalence of subclinical anterior uveitis in adult patients with inflammatory bowel diseases. Br J Ophthalmol, 2001; 85: 219–221.
22. Weinstein, JM., Koch, K., Lane, S.: Orbital pseudotumor in Crohn’s colitis. Ann Ophthalmol, 1984; 16: 275–278.
Labels
OphthalmologyArticle was published in
Czech and Slovak Ophthalmology
2011 Issue 3
Most read in this issue
- DMEK (Descemet Membrane Endothelial Keratoplasty) – Early and Late Postoperative Complications
- Lasik after Corneal Ulcer
- The Reconstruction of Conjunctival Socket after Enucleation of the Eye in Past – Two Possibilities of Surgical Solution
- Lyell’s Disease – a Case Report