Use of 5-fluorouracil in Trabeculectomy

Czech version

Authors: J. Novák; M. Hovorková; P. Rozsíval; J. Lochman; J. Kvasnička
Authors‘ workplace: Oční klinika FN, Hradec Králové, přednosta prof. MUDr. P. Rozsíval, CSc.
Published in: Čes. a slov. Oftal., , 2000, No. 6, p. 376-384
Category:

Overview

The cytostatic 5-fluorouracil (5-FU) is used at present in the postoperative treat-ment of glaucoma. In 1993-6 we administered by the subconjunctival route at theOphthalmological Clinic in Hradec Králové 5-FU to a group of 158 eyes aftertrabeculectomy (TE). The basic indication was ingrowth of the filtration vesicleor a rise of intraocular tension to 20 torr and more in 148 eyes. Preventively 5-FUwas administered during operation during revisions of TE in 10 eyes. In thementioned group with an unfavourable course of postoperative scar formation inthe wound we achieved during the investigation period of two years after surgerynormalization of the intraocular pressure to less than 16 torr without furthertreatment (we consider the value and condition without treatment as the optimalcondition) in 37% of cases and in 81% less than 20 torr with treatment.Side-effectsof administration of 5-FU (most frequently erosion of the corneal epithelium weretransient. For the mentioned indications 5-FU appears, being a cytostatic wherethe dosage can be exact, sufficiently safe for administration and it exerts anoptimal effect.

Key words:
trabeculectomy, 5-fluorouracil

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