Ofatumumab: State of the art in 2024 – Where are we now and where are we going

Czech version

Authors: M. Vališ ^1,2; S. Halúsková ^3,4
Authors‘ workplace: Research Institute for Biomedical, Science – Výzkumný ústav biomedicínských, věd, z. ú., Hradec Králové ¹; International Clinical Research Center, FN U sv. Anny v Brně ²; Neurologická klinika FZS Univerzity, Pardubice a Nemocnice Pardubického, kraje, Pardubice ³; Lékařská fakulta UK v Hradci Králové ⁴
Published in: Cesk Slov Neurol N 2024; 87(5): 313-316
Category: Review Article
doi: https://doi.org/10.48095/cccsnn2024313

Overview

Ofatumumab represents the first fully human anti-CD20 monoclonal antibody, developed for subcutaneous self-administration once a month. It is indicated for the treatment of active relapsing-remitting multiple sclerosis (RR-MS) and can be used as a first-line therapy in patients with negative prognostic factors suggestive of an unfavorable disease course. Ofatumumab demonstrated clear superiority over teriflunomide in registration clinical trials and long-term data from open-label extension studies which confirmed its sustained efficacy, favorable safety profile, and also a high level of patient compliance. From the patient‘s point of view, it is an attractive treatment option with a high-efficacy drug that is easy to administer via subcutaneous injection at home, requiring no premedication. Ofatumumab meets the requirements of modern pharmacotherapy and is one of the breakthrough drugs that can significantly improve the prognosis of patients with RR-MS.

Keywords:

compliance – Safety – Multiple sclerosis – ofatumumab – high effi cacy therapy – effi cacy

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