Subcutaneously delivered natalizumab for the treatment of highly active relapsing-remitting multiple sclerosis
Authors:
S. Halúsková; M. Vališ
Authors‘ workplace:
Neurologická klinika LF UK a FN Hradec Králové
Published in:
Cesk Slov Neurol N 2022; 85(3): 206-212
Category:
Review Article
doi:
https://doi.org/10.48095/cccsnn2022206
Overview
Therapeutic monoclonal antibodies (MAbs) have become one of the fastest growing classes of drugs, approved for the treatment of a wide range of indications. The development of new humanized and fully human MAbs has vastly improved their safety profile. Natalizumab is a humanized anti-α4-integrin monoclonal antibody, indicated as a single disease modifying therapy in adults with highly active relapsing-remitting multiple sclerosis. In 2021, natalizumab was authorized for use also as a subcutaneous injection. Clinical trials have shown that monthly subcutaneous injections of natalizumab are as safe and clinically and radiologically effective as monthly intravenous infusions.
Keywords:
Multiple sclerosis – Monoclonal antibodies – natalizumab – treatment – subcutaneous administration
Sources
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Paediatric neurology Neurosurgery NeurologyArticle was published in
Czech and Slovak Neurology and Neurosurgery
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