The Use of Optical Coherence Tomography in Multiple Sclerosis

Czech version

Authors: V. Matušková ¹; J. Lízrová Preiningerová ²; D. Vysloužilová ¹; M. Michalec ¹; Z. Kasl ³; E. Vlková ¹
Authors‘ workplace: Oční klinika LF MU a FN Brno ¹; Neurologická klinika a Centrum klinických neurověd, 1. LF UK a VFN v Praze ²; Oční klinika LF UK a FN Plzeň ³
Published in: Cesk Slov Neurol N 2016; 79/112(1): 33-40
Category: Review Article
doi: https://doi.org/10.14735/amcsnn201633

Overview

Optical coherence tomography is fast, non-invasive and reproducible imaging technique that provides detailed measurements of retinal structures. Retinal pathology in multiple sclerosis (MS) includes consequences of optic neuritis as well as diffuse degenerative changes. Thinning of retinal nerve fiber layer, decrease in total macular volume and loss of retinal ganglion cell layer correlate with visual acuity, brain atrophy measures and cognitive changes. Anterior visual pathway became a model of neuroaxonal injury in MS and is used to test neuroprotective effects of new therapies. The paper provides an overview of the physics of optical coherence tomography and its application in MS.

Key words:
optical coherence tomography – multiple sclerosis – retinal nerve fibre layer – total macular volume

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

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