#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Cognitive‑ communication Disorders in Patients with Dementia Due to Alzheimer’s Disease


Authors: J. Marková 1;  M. Králová 2;  J. Čunderlíková 1;  I. Hrubá 1;  M. Malík 3;  S. Šutovský 3;  P. Turčáni 3;  B. Mészáros-Hideghéty 2;  Z. Cséfalvay 1
Authors‘ workplace: Ústav psychologických a logopedických štúdií, Katedra logopédie, PdF UK v Bratislave 1;  Psychiatrická klinika LF UK a UN Bratislava 2;  I. neurologická klinika LF UK a UN Bratislava 3
Published in: Cesk Slov Neurol N 2015; 78/111(5): 536-541
Category: Original Paper

Overview

Purpose:
Our goal was to analyze language processes at a single-word, sentence and text levels in a group of patients with dementia due to Alzheimer´s disease (AD), and to describe the specific language impairments in this population.

Sample and methods:
Seventy-nine patients with AD participated in our study. To evaluate language processes, we used originally developed tests for Slovak language: Picture naming test, selected subtests from the Diagnostics of aphasia, alexia and agraphia language battery, Tests of sentence production, sentence comprehension and language processes at text level.

Results:
Comparison of all patients with different stages of AD with a control group showed significant difference between groups in sentence comprehension (Kruskal-Wallis 50.609; p < 0.001), sentence production (K-W 54.779; p < 0.001) and at text level (K-W 64.313; p < 0.001). The only significant difference found at a single-word level, was that between the control group and patients with severe AD in naming (lexical retrieval of nouns) (Mann-Whitney 22; p < 0.001), and there was a non-significant difference between patients groups and the control group at a single-word comprehension task (K-W 4.506; p = 0.212).

Conclusions:
A single-word comprehension task and the picture naming test are inadequate for early detection of existing higherlevel (sentence, text) language processing impairment in patients with AD-related dementia. Our results show that patients with mild AD perform poorer than matched healthy controls on language tasks at the sentence and text level. Sentences and text require activation of grammatical processes and processes linked to macrostructure and inference building.

Key words:
Alzheimer disease – language disorders – cognitive disorders

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.


Sources

1. Hort J, O‘Brien JT, Gainotti G, Pirttila T, Popescu BO, Rektorova I et al. EFNS guidelines for the dia­gnosis and management of Alzheimer‘s disease. Eur J Neurol 2010; 17(10): 1236– 1248. doi: 10.1111/ j.1468‑ 1331.2010.03040.x.

2. Bartoš A, Hasalíková M. Poznejte demenci správně a včas –  příručka pro klinickou praxi. Praha: Mladá fronta 2010.

3. Bayles K, Tomoeda Ch. Cognitive‑ comunnication disordes of dementia. CA: Plural Publishing 2007.

4. Bayles K. Understanding the neuropsychological syndrome of dementia. Semin Speech Lang 2001; 22(4): 251– 260.

5. Rektorová I. Neurodegenerativní demence. Cesk Slov Neurol N 2009; 72/ 105(2): 97– 109.

6. Fanfrdlová Z. Kognitivní deficity u Alzheimerovy demence. In: Priess M, Kučerová H (eds). Neuropsychologie v neurologii. Praha: Grada Publishing 2006: 123– 176.

7. Mahendra N, Hopper T. Dementia and related cognitive disorders. In: Papathanasiou I, Coppens P, Potagas C (eds). Aphasia and related neurogenic communication disorders. Burlington: Jones and Barlett Learning 2011: 397– 430.

8. Grossman M. Language in Dementia. In: Stemmer B, Whittaker H (eds). Handbook of the Neuroscience of Language. London: Elsevier 2008: 279– 287.

9. Grossman M, White‑ Devine T. Sentence comprehension in Alzheimer’s disease. Brain Lang 1998; 62(2): 186– 201.

10. Kepler D, Goral M. Language and dementia: neuropsychological aspects. Annu Rev Appl Linguist 2008; 28: 73– 90.

11. Emery O. Language impairment in dementia of the Alzheimer type: a hierachical decline? Int J Psychiatry Med 2000; 30(2): 145– 164.

12. Weiner MF, Neubecker KE, Bret ME, Hynan LS. Language in Alzheimer’sdisease. J Clin Psychiatry 2008; 69(8): 1223– 1227.

13. Nasreddine ZS, Phillips NA, Bédirian V, Charbon­neau S, Whitehead V, Collin I et al. The Montreal Cognitive Assessment (MoCA): a brief screening tool for mild cognitive impairment. J Am Geriatr Soc 2005; 53(4): 695– 699.

14. Hummelová‑ Fanfrdlová Z, Rektorová I, Sheardová K,Bartoš A, Línek V, Ressner P et al. Česká adaptace Addenbrookského kognitivního testu (Addenbrooke’s Cognitive Examination). Cesk Psychol 2009; 53(4): 376– 388.

15. Bartoš A, Čermáková P, Orlíková H, Al‑ Hajjar M, Řípová D. Soubor jednoznačně pojmenovatelných obrázků k hodnocení a léčbě jazykových a kognitivních deficitů. Cesk Slov Neurol N 2013; 76/ 109(4): 453– 462.

16. Košťálová M, Bednařík J, Mitášová A, Šajgalíková K, Demovičová A, Dušek L. Porovnání tíže afázie u demence a cévní mozkové příhody pomoci MASTcz a její vztah k tíži kognitivního deficitu. Cesk Slov Neurol N 2010; 73/ 106(3): 246– 252.

17. Hughes CP, Berg L, Danziger WL, Coben LA, Martin RL. A new clinical scale for the staging of dementia. Br J Psychiatry 1982; 140: 566– 572. Updated by Morris J. The CDR: current version and scoring rules. Neurology 1993; 43(11): 2412– 2414.

18. World Health Organization. ICD 10 International Codification of Diseases. 10th ed. 1990.

19. Šteňová V, Cséfalvay Z. Faktory ovplyvňujúce lexikálne vyhľadávanie v pomenovaní obrázkov: Test pomenovania obrázkov. Bratislava: SAL 2011.

20. Cséfalvay Z, Egryová M, WiedermannI. Dia­gnostika a terapia afázie, alexie a agrafie. Bratislava: Kaminský 2007.

21. Marková J, Cséfalvay Z, Mikulajová M, Schöffelová M.Analýza porozumenia viet v slovenčine. Test porozumenia viet s normami. Bratislava: Vydavateľstvo UK 2015.

22. Marková J. Test produkcie viet. Nepublikované sdělení.

23. Marková J, Matisová V. Test jazykových procesov na úrovni textu. Nepublikované sdělení.

Labels
Paediatric neurology Neurosurgery Neurology

Article was published in

Czech and Slovak Neurology and Neurosurgery

Issue 5

2015 Issue 5

Most read in this issue
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#