A Neurological Complication of Hepatitis E – a Case Study

Czech version

Authors: L. Petroušová ¹; L. Rožnovský ¹; J. Mrázek ²; A. Kloudová ²; P. Vašíčková ³; I. Woznicová ⁴
Authors‘ workplace: Klinika infekčního lékařství LF OU a FN Ostrava ¹; Oddělení molekulární biologie, Zdravotní ústav se sídlem v Ostravě ²; Výzkumný ústav veterinárního lékařství, v. v. i., Brno ³; Neurologická klinika LF OU a FN Ostrava ⁴
Published in: Cesk Slov Neurol N 2015; 78/111(2): 220-222
Category: Case Report

Overview

Neurological complications of acute hepatitis E are relatively rare. The case report describes mononeuropatia multiplex with aseptic meningitis in a 52‑year‑ old immunocompetent man. Viral hepatitis E was confirmed serologically and by polymerase chain reaction from the blood and cerebrospinal fluid (genotype 3f). Symptomatic treatment was given. Residual neurological deficit persisted six months after the onset of the disease. Diagnostic of hepatitis E should be considered in patients with concurrent neurological symptoms and liver cytolysis.

Key words:
hepatitis E – mononeuropatia multiplex

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

Sources

1. Trmal J, Pavlík I, Vašíčková P, Matějíčková L, Šimůnková L,Luks S et al. Epidemie virové hepatitidy E v České republice? Epidemiol Mikrobiol Imunol 2012; 61(1– 2): 15– 20.

2. Wedemeyer H, Pischke S, Manns MP. Pathogenesis and treatment of hepatitis E virus infection. Gastroenterology 2012; 142(6): 1388– 1397. doi: 10.1053/ j.gastro.2012.02.014.

3. Kamar N, Bendall RP, Peron JM, Cintas P, Mansuy JM,Rostaing L et al. Hepatitis E virus and neurologic disorders. Emerg Infect Dis 2011; 17(2): 173– 179. doi: 10.3201/ eid1702.100856.

4. Chalupa P, Holub M. Jaundice complicated by an atypical form of Guillain‑Barré syndrome. J Clin Virol 2010; 49(4): 229– 230. doi: 10.1016/ j.jcv.2010.07.017.

5. Despierres LA, Kaphan E, Attarian S, Cohen‑ Bacrie S, Pelletier J, Pouget J et al. Neurologic disorders and hepatitis E, France, 2010. Emerg Infect Dis 2011; 17(8): 1510– 1512. doi: 10.3201/ eid1708.102028.

6. Tse A, Cheung R, Ho SL, Chan KH. Guillain‑Barré syndrome associated with acute hepatitis E infection. J Clin Neurosci 2012; 19(4): 607– 608. doi: 10.1016/ j.jocn.2011.06.024.

7. Scharn N, Ganzenmueller T, Wenzel JJ, Dengler R, Heim A, Wegneret F. Guillain‑Barré syndrome associated with autochthonous infection by hepatitis E virus subgenotype 3c. Infection 2014; 42(1): 171– 173. doi: 10.1007/ s15010‑ 013‑ 0448‑ 5.

8. Moisset X, Vitello N, Bicilli E, Courtin R, Ferrier A, Taithe Fet al. Severe bilateral amyotrophic neuralgia associated with major dysphagia secondary to acute hepatitis E. F1000Res 2013; 2: 259. doi: 10.12688/ f1000research.2‑ 259.v2.

9. Santos L, Mesquita JR, Rocha Pereira N, Lima‑ Alves C, Serrão R, Figueiredo P et al. Acute hepatitis E complicated by Guillain‑Barré syndrome in Portugal, December 2012 – a case report. Euro Surveill 2013; 18(34): 20563.

10. Maurissen I, Jeurissen A, Strauven T, Sprengers D,De Schepperal B. First case of anti‑ganglioside GM1- positive Guillain‑Barré syndrome due to hepatitis E virus infection. Infection 2012; 40(3): 323– 326. doi: 10.1007/ s15010‑ 011‑ 0185‑ 6.