Barriers of Nervous System under Physiological and Pathological Conditions

Czech version

Authors: J. Piťha
Authors‘ workplace: Neurologická klinika 1. LF UK a VFN v Praze ; Neurologické oddělení, Krajská zdravotní, a. s. – Nemocnice Teplice, o. z.
Published in: Cesk Slov Neurol N 2014; 77/110(5): 553-559
Category: Review Article
doi: https://doi.org/10.14735/amcsnn2014553

Overview

Central and peripheral nervous systems are separated from the bloodstream by barrier structures that prevent free migration of water-soluble molecules through the tight junctions of the choroid plexus endothelial and epithelial cells. These barriers also play a role in the influx of essential molecules and elimination of xenobiotics. In recent years, differences and common features of the various barrier systems are being explored. Their disorders play a key role in a number of nervous system diseases. The present paper describes the structure and function of barrier systems under physiological and pathological conditions.

Key words:
blood brain barrier – blood nerve barrier – endotelial cells – astrocytes – pericytes

The author declare he has no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

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