Meningioma Diagnosis, Therapy and Follow-up at the Neurosurgery Clinic, University Hospital Brno between 2005 and 2010

Czech version

Authors: M. Duba; A. Mrlian; M. Smrčka; J. Musil
Authors‘ workplace: Neurochirurgická klinika LF MU a FN Brno
Published in: Cesk Slov Neurol N 2013; 76/109(2): 211-216
Category: Short Communication

Overview

Introduction:
Meningiomas are usually slow-growing tumors that arise from meningothelial cells and represent about one third of all primary intracranial tumors. They predominate in women. A patient may have multiple meningiomas. Clinical manifestations of meningiomas are determined by location and tumor size. Treatment is mostly surgical; success rate depends on the extent of resection. Radiotherapy is another treatment modality used, whilst hormonal therapy remains on experimental field.

Material and methods:
Authors describe their experience with the diagnosis, treatment and follow up of patients with meningioma (n = 314). Furthermore, they also assess postoperative morbidity and time to recurrence.

Results and conclusion:
Despite mostly benign histology of meningiomas, their recurrence is relatively frequent and oscillates between 10 to 30%, always in association with the extent of resection. Therefore, these patients should be followed up and regularly monitored using magnetic resonance imaging.

Key words:
meningioma – diagnostics – treatment – follow-up

Sources

1. Wiemels J, Wrensch M, Claus EB. Epidemiology and etiology of meningioma. J Neurooncol 2010; 99(3): 307–314.

2. Kane AJ, Sughrue ME, Rutkowski MJ, Shangari G, Fang S, McDermott MW et al. Anatomic location is a risk factor for atypical and malignant meningiomas. Cancer 2011; 117(6): 1272–1278.

3. Larjavaara S, Haapasalo H, Sankila R, Helén P, Auvinen A. Is the incidence of meningiomas underestimated? A regional survey. Br J Cancer 2008; 99: 182–184.

4. Claus EB, Bondy ML, Schildkraut JM, Wiemels JL, Wrensch M, Black PM. Epidemiology of intracranial meningioma. Neurosurgery 2005; 57(6): 1088–1095.

5. Dumanski JP, Carlbom E, Collins VP, Nordenskjöld M. Deletion mapping of a locus on human chromosome 22 involved in the oncogenesis of meningioma. Proc Natl Acad Sci USA 1987; 84: 9275–9279.

6. Seizinger BR, de la Monte S, Atkins L, Gusella JF, Martuza RL. Molecular genetic approach to human meningioma: loss of genes on chromosome 22. Proc Natl Acad Sci U S A 1987; 84: 5419–5423.

7. Koehorst SG, Jacobs HM, Thijssen JH, Blankenstein MA. Detection of an oestrogen receptor-like protein in human meningiomas by band shift assay using a synthetic oestrogen responsive element (ERE). Br J Cancer 1993; 68(2): 290–294.

8. Perrot-Applanat M, Groyer-Picard MT, Kujas M. Immunocytochemical study of progesterone receptor in human meningioma. Acta Neurochir (Wien) 1992; 115(1–2): 20–30.

9. Alexiou GA, Markoula S, Gogou P, Kyritsis AP. Genetic and molecular alterations in meningiomas. Clin Neurol Neurosurg 2011; 113(4): 261–267.

10. Sughrue ME, Kane AJ, Shangari G, Rutkowski MJ, McDermott MW, Berger MS, Parsa AT. The relevance of Simpson Grade I and II resection in modern neurosurgical treatment of World Health Organization Grade I meningiomas. J Neurosurg 2010; 113(5): 1029–1035.

11. Palma L, Celli P, Franco C, Cervoni L, Cantore G. Long-term prognosis for atypical and malignant meningiomas: a study of 71 surgical cases. Neurosurg Focus 1997; 2(4).

12. Kollová A, Liščák R, Šemnická J, Šimonová G, Vladyka V, Urgošík D. Dlhodobé výsledky liečby meningeómov Leksellovým gama nožom. Cesk Slov Neurol N 2010; 73/106(4): 415–421.

13. Pannullo SC, Fraser JF, Moliterno J, Cobb W, Stieg PE. Stereotactic radiosurgery: a meta-analysis of current therapeutic applications in neuro-oncologic disease. J Neurooncol 2011; 103(1): 1–17.

14. Pollock BE, Stafford SL, Utter A, Giannini C, Schreiner SA. Stereotactic radiosurgery provides equivalent tumor control to Simpson Grade 1 resection for patients with small- to medium-size meningiomas. Int J Radiat Oncol Biol Phys 2003; 55(4):1000–1005.

15. Náhlovský J et al. Neurochirurgie. 1st ed. Praha: Galén 2006.

16. Kozler P et al. Intrakraniální nádory. 1st ed. Praha: Galén 2007.

17. Palma L, Celli P, Franco C, Cervoni L, Cantore G. Long-term prognosis for atypical and malignant meningiomas: a study of 71 surgical cases. J Neurosurg 1997; 86: 793–800.

18. Younis GA, Sawaya R, DeMonte F, Hess KR, Albrecht S, Bruner JM. Aggressive meningeal tumors: review of a series. J Neurosurg 1995; 82: 17–27.

19. Bendszus M, Rao G, Burger R, Schaller C, Scheinemann K, Warmuth-Metz M et al. Is there a benefit of preoperative meningioma embolization? Neurosurgery 2000; 47(6): 1306–1311.

20. Schul DB, Wolf S, Krammer MJ, Landscheidt JF, Tomasino A, Lumenta CB. Meningioma surgery in the elderly: Outcome and validation of two proposed grading scores systems. Neurosurgery 2012; 70(3): 555–565.