IgE Antibody Serum Level Changes in Patients after Severe Head Injuries

Czech version

Authors: M. Smrčka; A. Mrlian; K. Ďuriš; J. Karlsson valik; M. Kýr ^*
Authors‘ workplace: Neurochirurgická klinika FN Brno ; 1. Dětská interní klinika FN Brno ^*
Published in: Cesk Slov Neurol N 2007; 70/103(3): 259-265
Category: Original Paper

Overview

Aim:
Transient IgE antibody serum level changes have been described in traumas, burns and after major surgical interventions. This might be caused by stress-induced immune system disturbances. These posttraumatic IgE changes, however, have not been described in neurotraumatology so far.

Material and Methods:
The study involved 35 patients after a severe head injury admitted to the Neurosurgical Department within 2004–5. The peripheral venous blood samples were collected from the patients in three-days´ intervals to study the levels of IgE, IgG, IgM, IgA antibodies and CRP. The dynamics of the IgE levels development was analysed in three samples dependent on the absolute IgE value of the first sample, on gender, GCS, GOS and the type of injury. Then the relation between the development of IgE, other antibodies and CRP was evaluated. The serum IgE values were established by LEIA (luminiscence – enhanced enzyme immunoassay). To normalise the data asymmetry the transformation was performed with the help of logarithm. The data were analysed by ANOVA test for repeated measurements.

Results:
The analysed group showed a significant increase of the IgE levels in time course (p < 0.001). No difference was found in the dynamics of the IgE level changes in relation to IgE value of the first sample, to gender, GOS and the type of injury (p = NS). In GCS 3 patients there was a significantly higher increase of the IgE levels between the second and third samples compared to patients with GCS 4–8 (p = 0,012). The increase of IgE levels if compared to other antibodies was extremely high. The dynamics of the CRP levels corresponded to inflammatory responses, which might be caused by a trauma.

Conclusions:
The report has confirmed a phenomenon of continuous increase in the IgE serum levels seen in patients after severe head injuries. The context of this finding with cellular immunosuppression after a head trauma and with high number of extracranial complications in these patients is not known so far.

Key words:
head injuries – immune system disturbances – immunoglobuline E

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