Osteoporosis and liver diseases
Authors:
Košcál Mojmír 1,2
Authors‘ workplace:
Interní oddělení – osteocentrum, Oblastní nemocnice Mladá Boleslav, a. s., nemocnice Středočeského kraje
1; Osteologické centrum FN Královké Vinohrady, Praha
2
Published in:
Clinical Osteology 2024; 29(4): 128-131
Category:
Overview
Increasing attention to the interaction between liver and bone has stimulated interest in targeted interventions for various forms of osteoporosis. Liver damage induced by various liver diseases can cause imbalances in bone metabolism, suggesting a new regulatory paradigm between liver and bone. However, the role of the liver in the development of osteoporosis is still not well understood. Therefore, investigating the precise regulatory mechanisms (liver–bone) may offer innovative clinical approaches to treat liver and bone-related diseases.
Keywords:
liver – liver disease – liver transplantation – osteoporosis – treatment
Sources
Nuti R, Brandi ML, Checchia G et al. Guidelines for the management of osteoporosis and fragility fractures. Intern Emerg Med 2018; 14(1): 85–102. Dostupné z DOI: <http://dx.doi.org/10.1007/s11739–018–1874–2>.
Burra P, Burroughsy A, Graziadei I et al. [European Association for the Study of the Liver]. EASL Clinical Practice Guidelines: Liver transplantation. J Hepatol 2016; 64(2): 433–485. Dostupné z DOI: <http://dx.doi.org/10.1016/j.jhep.2015.10.006>.
Guanabens N, Pares A. Osteoporosis in chronic liver disease. Liver Int 2018; 38(5): 776–785. Dostupné z DOI: <http://dx.doi.org/10.1111/liv.13730>.
Collier J, Ninkovic M, Compston J. Guidelines on the management of osteoporosis assciated with chronic liver disease. Gut 2002; 50(Suppl 1): i1–i9. Dostupné z DOI: <http://dx.doi.org/10.1136/gut.50.suppl_1.i1>.
Santos LA, Romeiro FG. Diagnosis and Management of Cirrhosis-Related Osteoporosis. Biomed Res Int 2016: 2016: 1423462. Dostupné z DOI: <http://dx.doi.org/10.1155/2016/1423462>.
Hirschfield GM, Beuers U, Corpechot C et al. [European Association for the Study of the Liver]. EASL Clinical Practice Guidelines: The diagnosis and management of patients with primary biliary cholangitis. J Hepatol. 2017; 67(1):145–172. Dostupné z DOI: <http://dx.doi.org/10.1016/j.jhep.2017.03.022>.
Merli M, Berzigotti A, Zelber-Sagi S et al. [European Association for the Study of the Liver]. EASL Clinical Practice Guidelines on nutrition in chronic liver disease. J Hepatol 2019; 70(1): 172–193. Dostupné z DOI: <http://dx.doi.org/10.1016/j.jhep.2018.06.024>.
Guss JD, Taylor E, Rouse Z et al. The microbial metagenome and bone tissue composition in mice with microbiome-induced reductions in bone strength. Bone 2019; 127: 146–154. Dostupné z DOI: <http://dx.doi.org/10.1016/j.bone.2019.06.010>.
Liu JM, Zhao HY, Ning G et al. IGF-1 as an early marker for low bone mass or osteoporosis in premenopausal and postmenopausal women. J Bone Miner Metab 2008; 26(2): 159–164. Dostupné z DOI: <http://dx.doi.org/10.1007/s00774–007–0799-z>.
Bellido T, Saini V, Pajevic PD. Effects of PTH on osteocyte function. Bone 2013; 54(2): 250–257. Dostupné z DOI: <http://dx.doi.org/10.1016/j.bone.2012.09.016>.
Boyce BF, Li P, Yao Z et al. TNF-alpha and pathologic bone resorption. Keio J Med 2005; 54(3): 127–131. Dostupné z DOI: <http://dx.doi.org/10.2302/kjm.54.127>.
Hsu E, Pacifici R. From osteoimmunology to osteomicrobiology: How the microbiota and the immune system regulate bone. Calcif Tissue Int 2018; 102(5): 512–521. Dostupné z DOI: <http://dx.doi.org/10.1007/s00223–017–0321–0>.
Das M, Cronin O, Keohane DM et al. Gut microbiota alterations associated with reduced bone mineral density in older adults. Rheumatology (Oxford) 2019; 58(12): 2295–2304. Dostupné z DOI: <http://dx.doi.org/10.1093/rheumatology/kez302>.
Nilsson AG, Sundh D, Backhed F et al. Lactobacillus reuteri reduces bone loss in older women with low bone mineral density: A randomized, placebo-controlled, double-blind, clinical trial. J Intern Med 2018; 284(3): 307–317. Dostupné z DOI: <http://dx.doi.org/10.1111/joim.12805>.
Lan GB, Xie XB, Peng LK et al. Current status of research on osteoporosis after solid organ transplantation: Pathogenesis and management. Biomed Res Int 2015: 2015: 413169. Dostupné z DOI: <http://dx.doi.org/10.1155/2015/413169>.
Loria L, Albanese C, Giusto M et al. Bone disorders in patients with chronic liver disease awaiting liver transplantation. Transplant Proc 2010; 42(4): 1191–1193. Dostupné z DOI: <http://dx.doi.org/10.1016/j.transproceed.2010.03.096>.
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Clinical biochemistry Paediatric gynaecology Paediatric radiology Paediatric rheumatology Endocrinology Gynaecology and obstetrics Internal medicine Orthopaedics General practitioner for adults Radiodiagnostics Rehabilitation Rheumatology Traumatology OsteologyArticle was published in
Clinical Osteology
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