Circadian rhythms and bone metabolism
Authors:
Palička Vladimír; Pavlíková Ladislava; Hyšpler Radomír
Authors‘ workplace:
Osteocentrum, Ústav klinické biochemie a diagnostiky FN Hradec Králové
Published in:
Clinical Osteology 2022; 27(4): 119-125
Category:
Overview
Circadian rhythms are extremely important regulators of the whole life. The main regulators are external (so called zeitgebers) deeply influenced by the changes in light and dark cycles. Internal regulators, represented by hormonal activities and gene expressions are part of bone metabolism too. Diurnal activities of bone resorption are easily documented by cyclic changes of CTx levels. Rhythmicity is regulated by food and fasting, sleep and its change by night shifts and physical activity. Chronotherapy is important in short-acting drugs, mostly.
Keywords:
Circadian rhythms – therapy – osteoporosis – bone metabolism – bone turnover markers
Sources
1. Albayrak I, Aydogmus M, Ozerbil OM et al. The association between bone mineral density, quality of life, quality of sleep and fatigue. Acta Clin Belg 2016; 71(2): 92–98. Dostupné z DOI: <http://dx.doi.org/10.1179/2295333715Y.0000000061>.
2. Willers C, Norton N, Harvey NC et al. Osteoporosis in Europe: a compendium of country-specific reports. Arch Osteoporos 2021; 17(1): 23. Dostupné z DOI: <http://dx.doi.org/10.1007/s11657–021–00969–8>.
3. Vandenput L, Johansson H, McCloskey EV et al. Update of the fracture risk prediction tool FRAX: a systematic review of potential cohorts and analysis plan. Osteoporos Int 2022; 33(10): 2103–2136. Dostupné z DOI: <http://dx.doi.org/10.1007/s00198–022–06435–6>.
4. LeBoff MS, Greenspan SL, Insogna KL et al. The clinician´s guide to prevention and treatment of osteoporosis. Osteoporos Int 2022; 33(10): 2049–2102. Dostupné z DOI: <http://dx.doi.org/10.1007/s00198–021–05900-y>.
5. Eckel-Mahan KL, Patel VR, Mohney RP et al. Coordination of the transcriptome and metabolome by the circadian clock. Proc Natl Acad Sci USA 2 012; 1 09(14): 5 541–5546. Dostupné z DOI: < http://dx.doi.org/10.1073/pnas.1118726109>.
6. Ruben MD, Smith DF, FitzGerald GA et al. Dosing time matters. Science 2 019; 3 65(6453): 5 47–549. Dostupné z DOI: < http://dx.doi.org/10.1126/science.aax7621>.
7. Partch CL, Green CB, Takahashi JS. Molecular architecture of the mammalian circadian clock. Trends Cell Biol 2014; 24(2): 90–99. Dostupné z DOI: <http://dx.doi.org/10.1016/j.tcb.2013.07.002>.
8. Winter EM, Kooijman S, Appelman-Dijkstra NM et al. Chronobiology and Chronotherapy of Osteoporosis JBMR Plus 2021; 5(10): e10504. Dostupné z DOI: <http://dx.doi.org/10.1002/jbm4.10504>.
9. Schilperoort M, van den Berg R, Dollé MET et al. Time-restricted feeding improves adaptation to chronically alternating light-dark cycles. Sci Rep 2019; 9(1):7874. Dostupné z DOI: <http://dx.doi.org/10.1038/s41598–019–44398–7>.
10. Hygum K, Starup-Linde J, Harslof T et al. The diurnal variation of bone formation is attenuated in adult patients with type 2 diabetes. Eur J Endocrinol 2 019; 1 81(3): 2 21–231. Dostupné z DOI: < http://dx.doi.org/10.1530/EJE-19–0309>.
11. Swanson C, Shea SA, Wolfe P et al. 24-hour profile of serum sclerostin and its association with bone biomarkers in men. Osteoporos Int 2017; 28(11): 3205–3213. Dostupné z DOI: <http://dx.doi.org/10.1007/s00198–017–4162–5>.
12. Borgen TT, Solberg LB, Lauritzen T et al. Target Values and Daytime Variation of Bone Turnover Markers in Monitoring Osteoporosis Treatment After Fractures. JBMR Plus 2022; 6(6): e10633. Dostupné z DOI: <http://dx.doi.org/10.1002/jbm4.10633>.
13. Smit AE, Schilperoort M, Winter EM. Restoring rhythm to prevent age-related fractures. Aging (Albany NY) 2022; 14(14): 5617–5619. Dostupné z DOI: <http://dx.doi.org/10.18632/aging.204192>.
14. Rogers TS, Harrison S, Swanson C et al. Rest-activity circadian rhythms and bone mineral density in elderly men. Bone Rep 2017; 7: 156–163. Dostupné z DOI: <http://dx.doi.org/10.1016/j.bonr.2017.11.001>.
15. Fujihara Y, Kondo H, Noguchi T, et al: Glucocorticoids mediate circadian timing in peripheral osteoclasts resulting in the circadian expression rhythm of osteoclast-related genes. Bone 2014; 61: 1–9. Dostupné z DOI: <http://dx.doi.org/10.1016/j.bone.2013.12.026>.
16. Bouchard AL, Dsouza CH, Julien C et al. Bone adaptation to mechanical loading in mice is affected by circadian rhythms. Bone 2022; 154: 116218. Dostupné z DOI: < http://dx.doi.org/10.1016/j.bone.2021.116218>.
17. Cunningham TD, Di Pace BS. Is Self-Reported Sleep Duration Associated with Osteoporosis? Data from a 4-Year Aggregated Analysis from the National Health and Nutrition Examination Survey. J Am Geriatr S oc 2 015; 6 3(7): 1401–1406. Dostupné z DOI: < http://dx.doi.org/10.1111/jgs.13477>.
18. Feskanich D, Hankinson SE, Schernhammer ES. Nightshift work and fracture risk: the Nurses´ Health Study. Osteoporos Int 2009; 20(4): 537–542. Dostupné z DOI: <http://dx.doi.org/10.1007/s00198–008–0729–5>.
19. Quevedo I, Zuniga AM. Low Bone Mineral Density in Rotating-Shift Workers. J Clin Densitom 2010; 13(4): 467–469. Dostupné z DOI: <http://dx.doi.org/10.1016/j.jocd.2010.07.004>.
20. Aoyama S, Shibata S. The Role of Circadian Rhythms in Muscular and Osseous Physiology and Their Regulation by Nutrition and Exercise. Front Neurosci 2017; 11: 63. Dostupné z DOI: <http://dx.doi.org/10.3389/fnins.2017.00063>.
21. Fensham NC, Heikura IA, McKay AKA et al. Short-Term Carbohydrate Restriction Impairs Bone Formation at Rest and During Prolonged Exercise to a Greater Degree than Low Energy Availability. J Bone Miner Res 2022; 37(10): 1915–1925. Dostupné z DOI: <http://dx.doi.org/10.1002/jbmr.4658>.
22. Qvist P, Christgau S, Pedersen BJ et al. Circadian Variation in the Serum Concentration of C-terminal Telopeptide of Type I Collagen (Serum CTx): Effects of Gender, Age, Menopausal Status, Posture, Daylight, S erum C ortisol, and Fasting. Bone 2 002; 3 1(1): 5 7–61. Dostupné z DOI: <http://dx.doi.org/10.1016/s8756–3282(02)00791–3>.
23. Henriksen DB, Alexandersen P, Bjarnarson NH et al. Role of Gastrointestinal Hormones in Postprandial Reduction of Bone Resorption. J Bone Miner Res 2003; 18(12): 2180–2189. Dostupné z DOI: <http://dx.doi.org/10.1359/jbmr.2003.18.12.2180>.
24. Caillot-Augusseau A, Lafage-Proust MH, Margaillan P et al. Weight gain reverses bone turnover and restores circadian variation of bone resorption in anorexic patients. Clin Endocrinol (Oxf) 2000; 5 2(1): 1 13–121. Dostupné z DOI: < http://dx.doi.org/10.1046/j.1365–2265.2000.00879.x>.
25. Schlemmer A, Ravn P, Hassager C et al. Morning or Evening Administration of Nasal Calcitonin? Effects on Biochemical Markers of Bone Turnover. Bone 1997; 20(1): 63–67. Dostupné z DOI: <http://dx.doi.org/10.1016/s8756–3282(96)00307–9>.
26. Karsdal MA, Byrjalsen I, Riis BJ et al. Investigation of the diurnal variation in bone resorption for optimal drug delivery and efficacy in osteoporosis with oral calcitonin. BMC C lin Pharmacol 2 008; 8 :12. Dostupné z DOI: <http://dx.doi.org/10.1186/1472–6904–8-12>.
27. Okubo N, Fujiwara H, Minami Y et al. Parathyroid hormone resets the cartilage circadian clock of the organ-cultured murine femur. Acta Orthopaed 2015; 86(5): 627–631.Dostupné z DOI: <http://dx.doi.org/10.3109/17453674.2015.1029393>.
28. Kunimoto T, Okubo N, Minami Y et al. A PTH-responsive circadian clock operates in ex vivo mouse femur fracture healing site. Sci Rep 2 016; 6 :22409. Dostupné z DOI: < http://dx.doi.org/10.1038/srep22409>.
29. Luchavova M, Zikan V, Michalska D et al. The effect of timing of teriparatide treatment on the circadian rhythm of bone turnover in postmenopausal osteoporosis. Eur J Endocrinol 2011; 164(4): 643–648. Dostupné z DOI: <http://dx.doi.org/.1530/EJE-10–1108>.
30. Michalska D, Luchavova M, Zikan V et al. Effects of morning vs. evening teriparatide injection on bone mineral density and bone turnover markers in postmenopausal osteoporosis. Osteoporos Int 2012; 23(12): 2885–2891. Dostupné z DOI: <http://dx.doi.org/10.1007/s00198–012–1955–4>.
31. Eastell R, Dijk DJ, Small M et al Morning vs evening dosing of the cathepsin K inhibitor ONO-5334: effects on bone resorption in postmenopausal women in a randomized, phase 1 trial. Osteoporos Int 2016; 27(1): 309–318. Dostupné z DOI: <http://dx.doi.org/10.1007/s00198–015–3342–4>.
32. Ando H, Otoda T, Ookami H et al Dosing time-dependent effect of raloxifene on plasma plasminogen activator inhibitor-1 concentrations in post-menopausal women with osteoporosis. Clin Exp Pharmacol Physiol 2 013; 4 0(3): 2 27–232. Dostupné z DOI: < http://dx.doi.org/10.1111/1440–1681.12055>.
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Clinical biochemistry Paediatric gynaecology Paediatric radiology Paediatric rheumatology Endocrinology Gynaecology and obstetrics Internal medicine Orthopaedics General practitioner for adults Radiodiagnostics Rehabilitation Rheumatology Traumatology OsteologyArticle was published in
Clinical Osteology
2022 Issue 4
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