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Effects of the gut microbiome on the bone tissue metabolism


Authors: Palička Vladimír
Authors‘ workplace: Osteocentrum, Ústav klinické biochemie a diagnostiky, LF v Hradci Králové UK a FN Hradec Králové
Published in: Clinical Osteology 2018; 23(1): 6-8
Category:

Overview

The links between different organs and tissues of the human body are multiple and many-sided. Until now, the skeletal system has been considered rather isolated. Recently, the extension of knowledge about the effects of hormones, immunity, nutrition, ions and other factors has considerably advanced. The latest studies demonstrate close relationship between the microbiome, especially the gut microbiome, and bone tissue metabolism. The gut microbiome undoubtedly affects healthy development of bone tissue in childhood and its remodelling in adulthood, absorption of calcium, and production of proinflammatory interleukins including RANKL through influencing the immune system. Estrogen deficiency loosens intercellular junctions of enterocytes and contributes to greater penetration of lipopolysaccharides, toxins and bacteria, and activation of chronic inflammation with a negative effect on bone metabolism. The largest amount of know­ledge has so far come from experimental animal studies, but its considerable part also applies to the human body.

Key words:

mikrobiom – osteoporosis

Received 30. 8. 2018

Accepted 4. 9. 2018


Sources
  1. Baumgart DC. Lidský mikrobiom. Medicína po Promoci 2016, 17(2): 94–99.

  2. D´Amelio P, Sassi F. Gut Microbiota, Immune System, and Bone. Calcif Tissue Int 2018; 102(4): 415–425.

  3. Grosicki GJ, Fielding RA, Lustgarten MS. Gut Microbiota Contribute to Age-Related Changes in Skeletal Muscle Size, Composition, and Function: Biological Basis for a Gut-Muscle Axis. Calcif Tissue Int 2018; 102(4): 433–442.

  4. Hernandez ChJ, Guss JD, Luna M, Goldring SR. Links between the Microbiome and Bone. J Bone Miner Res 2016; 31(9): 1638–1646.

  5. Chen Y, Shen H. Gut microbiome in liver disease. J Lab Prec Med 2016; 6. Dostupné z DOI: <http://doi: 10.21037/jlpm.2016.11.03>.

  6. Kashtanova DA, Popenko AS, Tkacheva ON et al. Association between the gut microbiota and diet: Fetal life, earl childhood, and further life. Nutrition 2016; 32(6): 620–627.

  7. Monsó E. Microbiome in chronic obstructive pulmonary disease. Ann Transl Med 2017; 5(12): 251. Dostupné z DOI: <http://doi: 10.21037/atm.2017.04.20>.

  8. Nagpal R, Yadav H. Bacterial Translocation from the Gut to the Distant Organs: An Overview. Ann Nutr Metab 2017; 71(Suppl 1): 11–16.

  9. Ohlsson C, Sjögren K. Osteomicrobiology: A New Cross-Disciplinary Research Field. Calcif Tissue Int 2018; 102(4): 426–432.

  10. Olszak T, An D, Zeissig S et al. Microbial exposure during early life has persistent effects on natural killer T cell function. Science 2012; 336(6080): 489–493.

  11. Semenkovich CF, Danska J, Darsow T et al. American Diabetes Association and JDRF Symposium: Diabetes and the Microbiome. Diabetes 2015; 64(12): 3967–3977.

  12. Sonnenburg JL, Bäckhed F. Diet-microbiota interactions as moderators of human metabolism. Nature 2016; 535(7610): 56–64.

  13. Steves CJ, Bird S, Williams FMK et al. The Microbiome and Musculoskeletal Conditions of Aging: A Review of Evidence for Impact and Potential Therapeutics. J Bone Miner Res 2016; 31(2): 261–269.

  14. Tremlett H, Waubant E. The multiple sclerosis microbiome? Ann Transl Med 2017; 5(3): 53. Dostupné z DOI: <http://doi: 10.21037/atm.2017.01.63>.

  15. Yadav VK, Balaji S, Suresh PS et al. Inhibition of gut-derived serotonin synthesis: a potential bone anabolic treatment. Nat Med 2010; 16(3): 308–312.

  16. Yan J, Charles JF. Gut Microbiota and IGF-1. Calcif Tissue Int 2018; 102(4): 406–414.

Labels
Clinical biochemistry Paediatric gynaecology Paediatric radiology Paediatric rheumatology Endocrinology Gynaecology and obstetrics Internal medicine Orthopaedics General practitioner for adults Radiodiagnostics Rehabilitation Rheumatology Traumatology Osteology
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