Immunotherapy in the treatment of non-small cell lung cancer
Authors:
O. Bílek; S. Bořilová; P. Grell; I. Kiss
Authors‘ workplace:
Klinika komplexní onkologické péče LF MU a MOÚ Brno
Published in:
Klin Onkol 2021; 34(Supplementum 1): 54-64
Category:
Review
doi:
https://doi.org/10.48095/ccko2021S54
Overview
Immunotherapy with check-point inhibitors has demonstrated remarkable therapeutic benefits in many oncological diagnoses, including non-small cell lung cancer (NSCLC). Based on the data from clinical trials, it has become an important part of the NSCLC treatment algorithm. Treatment with programmed cell death protein 1 / programmed death-ligand 1 inhibitors can be indicated in various ways: as monotherapy or combination of immunotherapy with cytotoxic T-lymphocyte antigen 4 inhibitors or in combination with other treatment modalities – chemotherapy, antiangiogenic therapy and radiotherapy. Regarding new spectrum of immune-related side effects, which require quick diagnosis and treatment, there is great urge to identify immunotherapy predictive biomarkers.
Keywords:
Non-small cell lung cancer – immunotherapy – programmed cell death protein 1
Sources
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