Squamous Cell Carcinoma in Localized Scleroderma
Authors:
V. Ďurčanská 1; H. Jedličková 1; O. Sláma 2; L. Velecký 3; E. Březinová 1; V. Vašků 1
Authors‘ workplace:
I. dermatovenerologická klinika LF MU a FN U sv. Anny v Brně
1; Klinika komplexní onkologické péče, Masarykův onkologický ústav, Brno
2; I. patologicko-anatomický ústav, LF MU a FN u sv. Anny v Brně
3
Published in:
Klin Onkol 2014; 27(6): 434-437
Category:
Case Report
doi:
https://doi.org/10.14735/amko2014434
Overview
We present a case of a young 26-year-old woman, who has been suffering from localised scleroderma (morphea) for 15 years. Recently, a lesion on the dorsum of her right foot ulcerated. Based on a CT scan and X-ray a diagnosis of ulcerative osteomyellitis was established. The patient was treated with a combination of antibiotics. Subsequent histological examinations showed granulomatous tissue and chronic inflammatory changes on top of pseudoepiteliomatous hyperplasia. The patient’s status was deteriorating, which resulted in a limb amputation under the knee. Three months later, there was a metastasis of squamous cell carcinoma found in the patient‘s inguinal lymph node. In spite of combined therapy (surgery, radioterapy and systemic chemotherapy), new metastases occurred and the patient succumbed to the disease several months afterwards. The case was concluded as a squamous cell carcinoma camouflaged by osteomyelitis. Malignant turn of localised sclerodema is very rare. It usually occurs on the lower extremities of patients with a long course of the disease and is associated with pansclerotic or generalised variants of morphea.
Key words:
localized scleroderma – squamous cell carcinoma – ulcer – osteomyelitis
The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.
The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.
Submitted:
17. 9. 2014
Accepted:
21. 10. 2014
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Labels
Paediatric clinical oncology Surgery Clinical oncologyArticle was published in
Clinical Oncology
2014 Issue 6
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