Case Report of a Patient with Advanced and Disseminated Gastric Carcinoma Treated by S-1

Czech version

Authors: J. Katolická ¹; S. Rotnáglová ¹; J. Vaníček ²
Authors‘ workplace: Onkologicko‑chirurgické oddělení, FN u sv. Anny v Brně ¹; Klinika zobrazovacích metod LF MU a FN u sv. Anny v Brně ²
Published in: Klin Onkol 2014; 27(3): 207-209
Category: Case Report

Overview

Background:
Prognosis of patients with metastatic gastric cancer is abysmal, usually just a few months. S-1 is a peroral fluoropyrimidine antitumor drug. It is a fixed combination of three effective drugs – tegafur, gimeracil and oteracil potassium.

Case:
This is a case report of a 71-year-old man treated for local advanced and metastatic gastric carcinoma treated with combination of S-1 and cisplatin as a first line of therapy. Treatment response reached partial remission and lasted for six months. Treatment was very well tolerated, with no grade 3 and 4 toxicity. After progression, the patient was treated with further lines of therapy.

Conclusion:
In the Czech Republic, experience with S-1 drug is very limited. Our case report showed a good treatment response and minimal toxicity of this treatment, in concordance with results of the study FLAGS.

Key words:
case report – metastatic gastric cancer – chemotherapy – S‑ 1 – cisplatin

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

Submitted:
12. 2. 2014

Accepted:
5. 5. 2014

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Article was published in

Clinical Oncology

2014 Issue 3