Cost Analysis of XELOX and FOLFOX-4 Chemotherapy Regimens for Colorectal Carcinoma
Authors:
T. Büchler 1; A. Nohejlová Medková 1; M. Kupec 1; M. Bláha 2; T. Pavlík 2; L. Dušek 2; J. Abrahámová 1
Authors‘ workplace:
Onkologická klinika 1. LF UK a Thomayerovy nemocnice, Praha
1; Institut biostatistiky a analýz, Masarykova univerzita, Brno
2
Published in:
Klin Onkol 2012; 25(6): 440-444
Category:
Original Articles
Práce byla podpořena grantem Operačního programu Vzdělávání pro konkurenceschopnost MZ ČR, EU a Evropského sociálního fondu v ČR: Edukační a informační platforma onkologických center pro podporu a modernizaci vzdělávání a lékařských a příbuzných medicínských oborech. CZ 2.07/2.4.00/31.0020.
TB a ANM dostali honoráře za přednášky od společností Roche a Medonet. Ostatní autoři prohlašují, že nemají konflikt zájmů.
Redakční rada potvrzuje, že rukopis práce splnil ICMJE kritéria pro publikace zasílané do bi omedicínských časopisů.
Overview
Background:
The aim of our study was to compare healthcare-related costs of treatment with XELOX and FOLFOX4 chemotherapeutic regimens in patients with colorectal cancer. We have evaluated costs claimed to the health insurance by the hospital administering these cancer therapies. This study is a pilot project utilising the new I-COP database developed by the Institute of Biostatistics and Analyses of the Masaryk University in Brno, Czech Republic.
Patients and Methods:
First, we estimated the costs based on current prices of procedures, medication, and materials from public sources. Using the I-COP database, we then carried out a matched-pair comparison of 26 patients treated with FOLFOX4 or XELOX for colorectal cancer. We evaluated a period of three months of therapy (i.e. 6 cycles of FOLFOX4 or 4 cycles of XELOX). Statistical analysis was done using the Wilcoxon matched pairs test.
Results:
The estimated cost for three months of therapy was 148,288 Czech crowns (CZK) for FOLFOX4 (including CZK 101,064 for chemotherapy drugs) and CZK 123,756 for XELOX. The overall costs claimed to the insurance companies were CZK 160,158 and CZK 151,176 for FOLFOX4 and XELOX, respectively (p = 0.221). The XELOX regimen had significantly higher costs for chemotherapy drugs (CZK 131,705 versus 114,531, p = 0.023) whereas other costs were lower than those for FOLFOX4.
Conclusions:
FOLFOX4 and XELOX regimens can be considered as equivalent in terms of costs claimed by the hospital administering cancer treatment.
Key words:
costs – cost analysis – chemotherapy – colorectal cancer
Sources
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Paediatric clinical oncology Surgery Clinical oncologyArticle was published in
Clinical Oncology
2012 Issue 6
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