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Iris Metastasis as the First Sign of Small Cell Lung Carcinoma with Metastatic Involvement of the Mediastinum


Authors: T. Jurečka 1,2;  Š. Skorkovská 1;  H. Čoupková 3;  V. Postránecká 4
Authors‘ workplace: Klinika nemocí očních a optometrie FN u sv. Anny a LF MU v Brně 2Oční klinika NeoVize, Brno 3Klinika komplexní onkologické péče, Masarykův onkologický ústav v Brně 4Klinika zobrazovacích metod FN u sv. Anny a LF MU v Brně 1
Published in: Klin Onkol 2009; 22(4): 179-182
Category: Case Reports

Overview

Backgrounds:
We present the case of small cell lung carcinoma metastatic to the iris, the course of the disease and management options.

Case:
A 69-year-old female was diagnosed with a solid, amelanotic iris mass in her left eye. Differential diagnostics and ancillary tests subsequently led to the diagnosis of disseminated small cell lung carcinoma. Systemic chemotherapy was indicated after fine needle biopsy verification of metastatic lung cancer. Iris metastasis responded well to the chemotherapy, its regression was observed and secondary open-angle glaucoma was controlled as well. Good visual functions were preserved during the treatment.

Conclusions:
Metastatic carcinoma of the iris may be the first sign of disseminated malignant disease. Small cell lung carcinoma iris metastasis can be treated with chemotherapy. This treatment preserved visual functions, which enhanced the patient‘s quality of life.

Key words:
iris metastasis – small cell lung carcinoma


Sources

1. Augsburger JJ, Guthoff R. Metastatic Cancer to the Eye. In: Yanoff M, Duker JS (eds.). Ophthalmology. 2nd ed. St. Louis: Mosby 2004: 1064–1069.

2. Souček P. Metastatické nádory. In: Baráková D (ed.). Nádory oka. Praha: Grada Publishing 2002: 101–103.

3. Shields JA, Shields CL, Kiratli H et al. Metastatic Tumors to the Iris in 40 Patients. Am J Ophthalmol 1995; 119(4): 422–430.

4. Pellantová E, Adámková H, Novák J et al. Metastatické postižení duhovkové tkáně při primárním karcinomu plic. Čes Slov Oftal 2002; 58(5): 315–318.

5. Demirci H, Shields CL, Chao AN et al. Uveal metastasis from breast cancer in 264 patients. Am J Ophthalmol 2003; 136(2): 264–271.

6. Yamada K, Hirata A, Kimura A et al. A case of primary B-cell type non Hodgkin lymphoma originating in the iris. Am J Ophthalmol 2003; 136(2): 380–382.

7. Capeáns C, Santos L, Sánchez-Salorio M et al. Iris Metastasis From Endometrial Carcinoma. Am J Ophthalmol 1998; 125(5): 729–730.

8. Imamura Y, Suzuki M, Nakajima KI et al. Gastric Signet Ring Cell Adenocarcinoma Metastatic to the Iris. Am J Ophthalmol 2001; 131(3): 379–381.

Labels
Paediatric clinical oncology Surgery Clinical oncology
Topics Journals
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