IKARUS Project – Incidence of Bone Events in Breast Cancer: Retrospective Analysis of Patients in Oncological Centres in the Czech Republic and Slovakia

Czech version

Authors: J. Fínek ¹; J. Prausová ²; V. Čmejlová ²; K. Cwiertka ³; H. Švébišová ³; R. Vyzula ⁴; M. Holánek; M. Bodorová ⁵; L. Slavíček ⁶; M. Kubecová ⁷; L. Loukotková ⁷; R. Neumanová ⁸; K. Lepeyová ⁹; M. Lysý ¹⁰; J. Šmejkal ¹⁰; R. Soumarová ¹¹; J. Ryšková ¹¹; K. Kališová ¹; J. Machanová ¹²; M. Bohušová ¹³; V. Alakša ¹⁴; M. Streško ¹⁵; T. Šamanová ¹; M. Kůta ¹⁶; J. Vaňásek ¹⁷; K. Vondráčková ¹⁷; M. Vargovčíková ¹⁸; J. Petera ¹⁹; E. Pritzova ²⁰; O. Bednařík ²¹; A. Hlaváčová ²¹; I. Jančoková ²²; O. Szeghöová ²³; A. Dammak ²⁴; J. Lešková ²⁵; K. Chroust ²⁶; L. Dušek ²⁶
Authors‘ workplace: Radioterapeutické a onkologické oddělení, FN Plzeň 2Radioterapeuticko onkologické oddělení, FN Praha Motol 3Onkologická klinika, FN Olomouc 4Klinika komplexní onkologické péče, MOÚ Brno 5Onkologicko rádioterapeutické oddelenie, Ústredná vojenská nemocnica ¹
Published in: Klin Onkol 2009; 22(4): 154-162
Category: Original Articles

Overview

Backgrounds:
Bone incidents today represent, in terms of frequency and the overall effect on the quality of life of patients with breast cancer, a serious health problem. In a number of clinical studies bisphosphonates have been shown to have a positive impact on reducing the risk of bone events and therefore to be effective in the prevention of bone events. The primary objective of this project was to identify the incidence of bone events in patients with metastatic breast cancer treated in the Czech and Slovak Republics. Subjects: Retrospective, multi centre, non interventional, epidemiological and explorative studies to identify the incidence of bone events in the defined group of patients and a description of the practice of prevention and treatment of skeletal events in the years 2000–2005. Enrolled were patients with advanced metastatic breast cancer diagnosed in 2000. Methods and Results: Analysis of overall survival and survival to disease progression, analysis of patterns of treatment of bone events and the practice of the use of bisphosphonates in the prevention of bone events in metastatic skeleton affection in the normal conditions of clinical practice, analysis of patient compliance in the treatment with bisphosphonates, analysis of the time interval between the occurrence of bone metastases and the occurrence of bone events and, last but not least, survival analysis of patients in relation to bone events. Conclusion: This work has shown that the practice of treatment with bisphosphonates since 2000 and assessed the survival of patients with metastatic breast cancer.

Key words:
breast cancer – bone event – bisphosphonate – survival – retrospective study

Sources

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Article was published in

Clinical Oncology

2009 Issue 4