Vitamin D and cardiovascular disease. What do we know about this in 2020?
Authors:
O. Mayer jr.
Authors‘ workplace:
II. interní klinika UK/LF a FN, Plzeň
Published in:
Klin. Biochem. Metab., 28, 2020, No. 3, p. 110-113
Overview
There is convincing evidence that vitamin D exerts important pathophysiological effects on the cardiovascular system. Low vitamin D status seems to be associated with increased cardiovascular risk in several reports. This review summarizes possible pathophysiological mechanisms for the role of low vitamin D status in cardiovascular diseases, existing epidemiologic evidence, as well as recently available data from interventional trials.
Keywords:
Calcitriol – cardiovascular disease – vascular calcification – vitamin supplementation
Sources
1. Norman, A. W. From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health. Am. J Clin. Nutr., 2008, 88, p. 491-9.
2. Somjen, D., Weisman, Y., Kohen, F., Gayer, B., Limor, R., Sharon, O., et al. 25-hydroxyvitamin D3-1alpha-hydroxylase is expressed in human vascular smooth muscle cells and is upregulated by parathyroid hormone and estrogenic compounds. Circulation. 2005, 111, p. 1666-71.
3. Hewison, M., Zehnder, D., Chakraverty, R., Adams, J. S. Vitamin D and barrier function: a novel role for extra-renal 1 alpha-hydroxylase. Mol. Cell Endocrinol., 2004, 215, p. 31-8.
4. Merke, J., Milde, P., Lewicka, S., Hugel, U., Klaus, G., Mangelsdorf, D. J. et al. Identification and regulation of 1,25-dihydroxyvitamin D3 receptor activity and biosynthesis of 1,25-dihydroxyvitamin D3. Studies in cultured bovine aortic endothelial cells and human dermal capillaries. J Clin. Invest., 1989, 83, p. 1903-15.
5. Martinesi, M., Bruni, S., Stio, M., Treves, C. 1,25-Dihydroxyvitamin D3 inhibits tumor necrosis factor-alpha-induced adhesion molecule expression in endothelial cells. Cell Biol. Int., 2006, 30, p. 365-75.
6. Kassi, E., Adamopoulos, C., Basdra, E. K., Papavassiliou, A. G. Role of vitamin D in atherosclerosis. Circulation. 2013, 128, p. 2517-31.
7. Freestone, T., Turner, R. J., Coady, A., Higman, D. J., Greenhalgh, R. M., Powell, J. T. Inflammation and matrix metalloproteinases in the enlarging abdominal aortic aneurysm. Arterioscler. Thromb. Vasc. Biol., 1995, 15, p. 1145-51.
8. Perovic, M., Obradovic, M., Resanovic, I., Isenovic, E. R. Editorial: Relationship between Vitamin D and Metalloproteinases (MMPs) in Acute Myocardial Infarction (AMI). Curr Vasc Pharmacol. United Arab. Emirates, 2018, p. 361-2.
9. O’Connell, T. D., Berry, J. E., Jarvis, A. K., Somerman, M. J., Simpson, R. U. 1,25-Dihydroxyvitamin D3 regulation of cardiac myocyte proliferation and hypertrophy. Am. J Physiol., 1997, 272, p. 1751-8.
10. Tishkoff, D. X., Nibbelink, K. A., Holmberg, K. H., Dandu, L., Simpson, R. U. Functional vitamin D receptor (VDR) in the t-tubules of cardiac myocytes: VDR knockout cardiomyocyte contractility. Endocrinology, 2008, 149, p. 558-64.
11. Simpson, R. U., Hershey, S. H., Nibbelink, K. A. Characterization of heart size and blood pressure in the vitamin D receptor knockout mouse. J Steroid. Biochem. Mol. Biol., 2007, 103, p. 521-4.
12. Mancuso, P., Rahman, A., Hershey, S. D., Dandu, L., Nibbelink, K. A., Simpson, R. U. 1,25-Dihydroxyvitamin-D3 treatment reduces cardiac hypertrophy and left ventricular diameter in spontaneously hypertensive heart failure-prone (cp/+) rats independent of changes in serum leptin. J Cardiovasc. Pharmacol., 2008, 51, p. 559-64.
13. Zittermann, A., Schleithoff, S. S., Gotting, C., Dronow, O., Fuchs, U., Kuhn, J. et al. Poor outcome in end-stage heart failure patients with low circulating calcitriol levels. Eur. J Heart. Fail., 2008, 10, p. 321-7.
14. Zittermann, A., Koerfer, R. Protective and toxic effects of vitamin D on vascular calcification: clinical implications. Mol. Aspects Med., 2008, 29, p. 423-32.
15. Timms, P. M., Mannan, N., Hitman, G. A., Noonan, K., Mills, P. G., Syndercombe-Court, D. et al. Circulating MMP9, vitamin D and variation in the TIMP-1 response with VDR genotype: mechanisms for inflammatory damage in chronic disorders? Qjm., 2002, 95, p. 787-96.
16. Shao, J. S., Cheng, S. L., Sadhu, J., Towler, D. A. Inflammation and the osteogenic regulation of vascular calcification: a review and perspective. Hypertension. 2010, 55, p. 579-92.
17. Towler, D. A., Shao, J. S., Cheng, S. L., Pingsterhaus, J. M., Loewy, A. P. Osteogenic regulation of vascular calcification. Ann. N Y Acad. Sci., 2006, 1068, p. 327-33.
18. Zebboudj, A. F., Shin, V., Bostrom, K. Matrix GLA protein and BMP-2 regulate osteoinduction in calcifying vascular cells. J Cell Biochem., 2003, 90, p. 756-65.
19. Schmidt, N., Brandsch, C., Kuhne, H., Thiele, A., Hirche, F., Stangl, G. I. Vitamin D receptor deficiency and low vitamin D diet stimulate aortic calcification and osteogenic key factor expression in mice. PLoS One. 2012, 7, e35316.
20. Cancela, L., Hsieh, C. L., Francke, U., Price, P. A. Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene. J Biol. Chem., 1990, 265, p. 15040-8.
21. Fraser, J. D., Otawara, Y., Price, P. A. 1,25-Dihydroxyvitamin D3 stimulates the synthesis of matrix gamma-carboxyglutamic acid protein by osteosarcoma cells. Mutually exclusive expression of vitamin K-dependent bone proteins by clonal osteoblastic cell lines. J Biol. Chem., 1988, 263, p. 911-6.
22. London, G. M., Guerin, A. P., Verbeke, F. H., Pannier, B., Boutouyrie, P., Marchais, S. J. et al. Mineral metabolism and arterial functions in end-stage renal di-sease: potential role of 25-hydroxyvitamin D deficiency. J Am. Soc. Nephrol., 2007, 18, p. 613-20.
23. Mayer, O. Jr., Filipovsky, J., Seidlerova, J., Vanek, J., Dolejsova, M., Vrzalova, J. et al. The association between low 25-hydroxyvitamin D and increased aortic stiffness. J Hum. Hypertens., 2012, 26, 650-5.
24. Giallauria, F., Milaneschi, Y., Tanaka, T., Maggio, M., Canepa, M., Elango, P. et al. Arterial stiffness and vitamin D levels: the Baltimore longitudinal study of aging. J Clin. Endocrinol. Metab., 2012, 97, p. 3717-23.
25. Jha, P., Dolan, L. M., Khoury, P. R., Urbina, E. M., Kimball, T. R., Shah, A. S. Low Serum Vitamin D Le-vels Are Associated With Increased Arterial Stiffness in Youth With Type 2 Diabetes. Diabetes Care, 2015, 38, p. 1551-7.
26. Sabio, J. M., Vargas-Hitos, J. A., Martinez-Bordonado, J., Navarrete-Navarrete, N., Diaz-Chamorro, A., Olvera-Porcel, C. et al. Association between low 25-hydroxyvitamin D, insulin resistance and arterial stiffness in nondiabetic women with systemic lupus erythematosus. Lupus, 2015, 24, p. 155-63.
27. Kuloglu, O., Gur, M., Seker, T., Kalkan, G. Y., Sahin, D. Y., Tanboga, I. H. et al. Serum 25-hydroxyvitamin D level is associated with arterial stiffness, left ventricle hypertrophy, and inflammation in newly diagnosed hypertension. J Investig. Med., 2013, 61, p. 989-94.
28. Lee, S., Ahuja, V., Masaki, K., Evans, R. W., Barinas-Mitchell, E. J., Ueshima, H., et al. A Significant Positive Association of Vitamin D Deficiency with Coronary Artery Calcification among Middle-aged Men: For the ERA JUMP Study. J Am. Coll. Nutr., 2016, 35, p. 614-20.
29. Lai, S., Fishman, E. K., Gerstenblith, G., Brinker, J., Tai, H., Chen, S. et al. Vitamin D deficiency is associated with coronary artery calcification in cardiovascularly asymptomatic African Americans with HIV infection. Vasc. Health Risk Manag., 2013, 9, p. 493-500.
30. Linhartova, K., Veselka, J., Sterbakova, G., Racek, J., Topolcan, O., Cerbak, R. Parathyroid hormone and vitamin D levels are independently associated with calcific aortic stenosis. Circ. J., 2008, 72, p. 245-50.
31. Wang, T. J., Pencina, M. J., Booth, S. L., Jacques, P. F., Ingelsson, E., Lanier, K. et al. Vitamin D deficiency and risk of cardiovascular disease. Circulation, 2008, 117, p. 503-11.
32. Giovannucci, E., Liu, Y., Hollis, B. W., Rimm, E. B. 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Arch. Intern. Med., 2008, 168, p. 1174-80.
33. Dobnig, H., Pilz, S., Scharnagl, H., Renner, W., Seelhorst, U., Wellnitz, B. et al. Independent association of low serum 25-hydroxyvitamin d and 1,25-dihydroxyvitamin d levels with all-cause and cardiovascular mortality. Arch. Intern. Med., 2008, 168, p. 1340-9.
34. Autier, P., Gandini, S. Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials. Arch. Intern. Med., 2007, 167, p. 1730-7.
35. Trivedi, D. P., Doll, R., Khaw, K. T. Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. Bmj., 2003, 326, p. 469.
36. Hsia, J., Heiss, G., Ren, H., Allison, M., Dolan, N. C., Greenland, P. et al. Calcium/vitamin D supplementation and cardiovascular events. Circulation, 2007, 115, p. 846-54.
37. Kovesdy, C. P., Ahmadzadeh, S., Anderson, J. E., Kalantar-Zadeh, K. Association of activated vitamin D treatment and mortality in chronic kidney disease. Arch. Intern. Med., 2008, 168, p. 397-403.
38. Manson, J. E., Cook, N. R., Lee, I. M., Christen, W., Bassuk, S. S., Mora, S. et al. Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease. N Engl. J Med., 2019, 380, p. 33-44.
39. Scragg, R., Stewart, A. W., Waayer, D., Lawes, C. M. M., Toop, L., Sluyter, J. et al. Effect of Monthly High-Dose Vitamin D Supplementation on Cardiovascular Di-sease in the Vitamin D Assessment Study : A Randomized Clinical Trial. JAMA Cardiol., 2017, 2, p. 608-16.
40. Zittermann, A., Ernst, J. B., Prokop, S., Fuchs, U., Dreier, J., Kuhn, J. et al. Effect of vitamin D on all-cause mortality in heart failure (EVITA): a 3-year randomized clinical trial with 4000 IU vitamin D daily. Eur. Heart. J., 2017, 38, p. 2279-86.
41. Barbarawi, M., Kheiri, B., Zayed, Y., Barbarawi, O., Dhillon, H., Swaid, B. et al. Vitamin D Supplementation and Cardiovascular Disease Risks in More Than 83000 Individuals in 21 Randomized Clinical Trials: A Meta-analysis. JAMA Cardiol., 2019, 4, p. 765-76.
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Clinical biochemistry Nuclear medicine Nutritive therapistArticle was published in
Clinical Biochemistry and Metabolism
2020 Issue 3
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