Positive association of adiponectin with adipocyte fatty acid binding protein in patients with unfavourable dyslipidemic phenotype

Czech version

Authors: D. Novotný ¹; H. Vaverková ²; D. Karásek ²; M. Bartková ¹; J. Lukeš ¹
Authors‘ workplace: Oddělení klinické biochemie, Fakultní nemocnice Olomouc, I. P. Pavlova 6, 775 0 Olomouc, Česká republika ¹; III. Interní klinika Lékařské fakulty Univerzity Palackého a Fakultní nemocnice Olomouc, I. P. Pavlova 6, 775 20 Olomouc, Česká republika ²
Published in: Klin. Biochem. Metab., 22 (43), 2014, No. 3, p. 116-122

Overview

Objective:
We examined 214 asymptomatic dyslipidemic individuals divided into two groups, DLP1 (n = 66) and DLP2 (n = 148), according to triglyceride (TG) and apolipoprotein B (Apo B) levels. The aim of our study was to evaluate the relationship of adiponectin (ADP) with adipocyte fatty acid binding protein (A-FABP), and to elucidate possible associations to lipid parameters, markers of insulin resistance and endothelial haemostatic markers in observed groups.

Design:
prospective observational

Results:
In DLP2 group (TG ≥ 1.5 mmol and/or Apo B ≥ 1.2 g/l), we found the positive correlations of ADP with age, HDL cholesterol, apolipoprotein A1, N-terminal prohormone of brain natriuretic peptide, von Willebrand factor and A-FABP, and the negative correlation with body mass index, waist circumference, TG, atherogenic index of plasma, insulin, C-peptide and proinsulin. In the same group, the significant positive correlations of A-FABP with age, body mass index, waist circumference, C- reactive protein, N-terminal prohormone of brain natriuretic peptide, von Willebrand factor, plasminogen activator inhibitor-1, C-peptide, proinsulin and ADP were observed. The multiple regression analysis with adipokines as dependent variables and correlated parameters as independent predictors revealed the independent positive relationship of ADP with age (beta = 0.3764, p<0.0080) and A-FABP (beta = 0.2062, p = 0.0111). In DLP2 group, we also found the independent positive association of A-FABP with body mass index (beta = 1.0375, p = 0.0107) and ADP (beta = 0.2322, p = 0.0088), in contrast to DLP1 group.

Conclusion:
The independent positive reciprocal association of ADP with A-FABP in subjects with unfavourable dyslipidemic phenotype could be related to the higher cardiovascular risk.

Keywords:
dyslipidemia, adipokines, adiponectin, adipocyte fatty acid binding protein, von Willebrand factor

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Clinical Biochemistry and Metabolism

2014 Issue 3