The importance of selected laboratory parameters for the diagnostics, stratification and monitoring of AL amyloidosis patients
Authors:
T. Pika 1; P. Lochman 2; P. Flodr 3; J. Minařík 1; P. Látalová 3; J. Bačovský 1; V. Ščudla 1
Authors‘ workplace:
III. interní klinika – nefrologická, revmatologická, endokrinologická, LF UP a FN Olomouc
1; Oddělení klinické biochemie, FN Olomouc
2; Ústav klinické a molekulární patologie, LF UP a FN Olomouc
3
Published in:
Klin. Biochem. Metab., 21 (42), 2013, No. 2, p. 79-82
Overview
Objective:
The objective of this report is to point out the clinical importance of select biological indicators applied to diagnostics and monitoring of AL amyloidosis patients. In addition to the usual parameters such as urine analysis or the monoclonal immunoglobulin level assay, the benefits of free light immunoglobulin chains serum level assay and its application to treatment response evaluation are pointed out, as well as the benefits of heart indicator assays (troponins and natriuretic peptides) for the stratification of AL amyloidosis patients. A brief introduction of this rare diagnosis is also included in the report.
Key words:
AL amyloidosis, free light immunoglobulin chains, troponins, natriuretic peptides.
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