COSYREL – a drug for patients with coronary artery disease and heart failure

Czech version

Authors: J. Špinar ¹; J. Vítovec ²
Authors‘ workplace: Interní kardiologická klinika LF MU a FN Brno, Brno ¹; I. interní kardioangiologická klinika LF MU a FN u sv. Anny v Brně ²
Published in: Kardiol Rev Int Med 2017, 19(1): 62-67

Overview

Fixed combinations increase the adherence/ compliance of patients to treatment and so increase the disease control. 5 basic drug groups are recommended for the treatment of hypertension and the main role plays the RAAS blockade, especially ACE inhibitors. These are combined with calcium channel blockade dihydropyridines or metabolically neutral indapamid especially in patients with metabolic syndrome. The combination with betablockers is recommended in patients with ischemic heart disease. Cosyrel is the first fixed combination of betablockers (bisoprolol fumarate) and ACE inhibitor (perindopril arginin) available on Czech market. The drug is indicated in patients with ischemic heart disease, hypertension and/ or heart failure (doses 5 mg bisoprolol/ 5 mg perindopril, 10 mg bisoprolol/ 5 mg perindopril). The combination of perindopril + betablockers decreases the primary endpoint (cardiovascular mortality, nonfatal MI a resuscitation) by 24%, fatal and nonfatal MI by 28%, hospitalisation for heart failure by 45% and all-cause mortality by 13% in the EUROPA trial.

Keywords:
hypertension – heart failure – perindopril – bisoprolol

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